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@ARTICLE{Hubcik:288650,
      author       = {Hubcik, Lukas and Funari, Sergio de Souza and Pullmannova,
                      Petra and Ferdinand, Devinsky and Uhrikova, Daniela},
      title        = {{S}timuli responsive polymorphism of
                      $\mathrm{{C}_{12}{NO}/{DOPE}/{DNA}}$ complexes: {E}ffect of
                      p{H}, tempertaure and composition},
      journal      = {Biochimica et biophysica acta / Biomembranes},
      volume       = {1848},
      number       = {5},
      issn         = {0005-2736},
      address      = {Amsterdam},
      publisher    = {Elsevier},
      reportid     = {PUBDB-2015-05110},
      pages        = {1127 - 1138},
      year         = {2015},
      note         = {(c) Elsevier B.V. Post referee full text in progress.
                      Embargo for post referee full text 1 year from 07.02.2015.},
      abstract     = {N$_{,}$N-dimethyldodecylamine-N-oxide (C12NO) is a
                      surfactant that may exist either in a neutral or cationic
                      protonated form depending on the pH of aqueous solutions.
                      Using small angle X-ray diffraction (SAXD) we observe the
                      rich structural polymorphism of pH responsive complexes
                      prepared due to DNA interaction with
                      C12NO/dioleoylphosphatidylethanolamine (DOPE) vesicles and
                      discuss it in view of utilizing the surfactant for the gene
                      delivery vector of a pH sensitive system. In neutral
                      solutions, the DNA uptake is low, and a lamellar Lα phase
                      formed by C12NO/DOPE is prevailing in the complexes at
                      0.2≤C12NO/DOPE<0.6 mol/mol. A maximum of ~30\% of the
                      total DNA volume in the sample is bound in a condensed
                      lamellar phase LαC at C12NO/DOPE=1 mol/mol and pH7.2. In
                      acidic conditions, a condensed inverted hexagonal phase HIIC
                      was observed at C12NO/DOPE=0.2 mol/mol. Commensurate lattice
                      parameters, aHC≈dLC, were detected at
                      0.3≤C12NO/DOPE≤0.4 mol/mol and pH=4.9-6.4 suggesting
                      that LαC and HIIC phases were epitaxially related. While at
                      the same composition but pH~7, the mixture forms a cubic
                      phase (Pn3m) when the complexes were heated to 80°C and
                      cooled down to 20°C. Finally, a large portion of the
                      surfactant (C12NO/DOPE>0.5) stabilizes the LαC phase in
                      C12NO/DOPE/DNA complexes and the distance between DNA
                      strands (dDNA) is modulated by the pH value. Both the
                      composition and pH affect the DNA binding in the complexes
                      reaching up to ~95\% of the DNA total amount at acidic
                      conditions.},
      cin          = {DOOR},
      ddc          = {570},
      cid          = {I:(DE-H253)HAS-User-20120731},
      pnm          = {6215 - Soft Matter, Health and Life Sciences (POF3-621) /
                      FS-Proposal: II-20100372 EC (II-20100372-EC)},
      pid          = {G:(DE-HGF)POF3-6215 / G:(DE-H253)II-20100372-EC},
      experiment   = {EXP:(DE-H253)D-A2-20150101},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000352041100007},
      pubmed       = {pmid:25660321},
      doi          = {10.1016/j.bbamem.2015.01.020},
      url          = {https://bib-pubdb1.desy.de/record/288650},
}