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@ARTICLE{Barends:209217,
      author       = {Barends, Thomas and White, Thomas and Barty, Anton and
                      Foucar, Lutz and Messerschmidt, Marc and Alonso-Mori,
                      Roberto and Botha, Sabine and Chapman, Henry and Doak, R.
                      Bruce and Galli, Lorenzo and Gati, Cornelius and Gutmann,
                      Matthias and Koglin, Jason and Markvardsen, Anders and Nass,
                      Karol and Oberthur, Dominik and Shoeman, Robert and
                      Schlichting, Ilme and Boutet, Sébastien},
      title        = {{E}ffects of self-seeding and crystal post-selection on the
                      quality of {M}onte {C}arlo-integrated {SFX} data},
      journal      = {Journal of synchrotron radiation},
      volume       = {22},
      number       = {3},
      issn         = {1600-5775},
      address      = {Chester},
      publisher    = {IUCr},
      reportid     = {PUBDB-2015-02033},
      pages        = {1-9},
      year         = {2015},
      note         = {(c) International Union of Crystallography},
      abstract     = {Serial femtosecond crystallography (SFX) is an emerging
                      method for data collection at free-electron lasers (FELs) in
                      which single diffraction snapshots are taken from a large
                      number of crystals. The partial intensities collected in
                      this way are then combined in a scheme called Monte Carlo
                      integration, which provides the full diffraction
                      intensities. However, apart from having to perform this
                      merging, the Monte Carlo integration must also average out
                      all variations in crystal quality, crystal size, X-ray beam
                      properties and other factors, necessitating data collection
                      from thousands of crystals. Because the pulses provided by
                      FELs running in the typical self-amplified spontaneous
                      emission (SASE) mode of operation have very irregular, spiky
                      spectra that vary strongly from pulse to pulse, it has been
                      suggested that this is an important source of variation
                      contributing to inaccuracies in the intensities, and that,
                      by using monochromatic pulses produced through a process
                      called self-seeding, fewer images might be needed for Monte
                      Carlo integration to converge, resulting in more accurate
                      data. This paper reports the results of two experiments
                      performed at the Linac Coherent Light Source in which data
                      collected in both SASE and self-seeded mode were compared.
                      Importantly, no improvement attributable to the use of
                      self-seeding was detected. In addition, other possible
                      sources of variation that affect SFX data quality were
                      investigated, such as crystal-to-crystal variations
                      reflected in the unit-cell parameters; however, these
                      factors were found to have no influence on data quality
                      either. Possibly, there is another source of variation as
                      yet undetected that affects SFX data quality much more than
                      any of the factors investigated here.},
      cin          = {FS-CFEL-1},
      ddc          = {540},
      cid          = {I:(DE-H253)FS-CFEL-1-20120731},
      pnm          = {6215 - Soft Matter, Health and Life Sciences (POF3-621)},
      pid          = {G:(DE-HGF)POF3-6215},
      experiment   = {EXP:(DE-H253)CFEL-Exp-20150101},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000353920300027},
      pubmed       = {pmid:25931080},
      doi          = {10.1107/S1600577515005184},
      url          = {https://bib-pubdb1.desy.de/record/209217},
}