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@ARTICLE{Pogenberg:207457,
      author       = {Pogenberg, Vivian and Consani Textor, Larissa and
                      Vanhille, Laurent and Holton, Simon J. and Sieweke,
                      Michael H. and Wilmanns, Matthias},
      title        = {{D}esign of a b{Z}ip {T}ranscription {F}actor with
                      {H}omo/{H}eterodimer-{I}nduced {DNA}-{B}inding {P}reference},
      journal      = {Structure},
      volume       = {22},
      number       = {3},
      issn         = {0969-2126},
      address      = {London [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {PUBDB-2015-01355},
      pages        = {466 - 477},
      year         = {2014},
      note         = {© Elsevier Ltd. Open Archive},
      abstract     = {The ability of basic leucine zipper transcription factors
                      for homo- or heterodimerization provides a paradigm for
                      combinatorial control of eukaryotic gene expression. It has
                      been unclear, however, how facultative dimerization results
                      in alternative DNA-binding repertoires on distinct
                      regulatory elements. To unravel the molecular basis of such
                      coupled preferences, we determined two high-resolution
                      structures of the transcription factor MafB as a homodimer
                      and as a heterodimer with c-Fos bound to variants of the
                      Maf-recognition element. The structures revealed several
                      unexpected and dimer-specific coiled-coil-heptad
                      interactions. Based on these findings, we have engineered
                      two MafB mutants with opposite dimerization preferences. One
                      of them showed a strong preference for MafB/c-Fos
                      heterodimerization and enabled selection of
                      heterodimer-favoring over homodimer-specific Maf-recognition
                      element variants. Our data provide a concept for
                      transcription factor design to selectively activate
                      dimer-specific pathways and binding repertoires.},
      cin          = {EMBL},
      ddc          = {570},
      cid          = {I:(DE-H253)EMBL-20120731},
      pnm          = {DORIS Beamline BW7 (POF2-54G13) / DORIS Beamline K1.3
                      (POF2-54G13)},
      pid          = {G:(DE-H253)POF2-BW7-20130405 /
                      G:(DE-H253)POF2-K1.3-20130405},
      experiment   = {EXP:(DE-H253)D-BW7-20150101 / EXP:(DE-H253)D-K1.3-20150101},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000333025700012},
      pubmed       = {pmid:24530283},
      doi          = {10.1016/j.str.2013.12.017},
      url          = {https://bib-pubdb1.desy.de/record/207457},
}