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100 | 1 | _ | |0 P:(DE-HGF)0 |a Stalder, Anja K. |b 0 |
245 | _ | _ | |a Combined use of micro computed tomography and histology to evaluate the regenerative capacity of bone grafting materials |
260 | _ | _ | |a München |b Hanser |c 2014 |
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336 | 7 | _ | |0 PUB:(DE-HGF)16 |2 PUB:(DE-HGF) |a Journal Article |b journal |m journal |s 1436436468_22349 |
336 | 7 | _ | |2 BibTeX |a ARTICLE |
500 | _ | _ | |a (c) Carl Hanser Verlag GmbH & Co. KG. Post referee fulltext in progress. |
520 | _ | _ | |a Pre-clinical animal models are commonly used to evaluate the osteogenic potential of bone grafting materials in-vivo. Based on the histology analysis, the currently commercially available bone grafting materials show comparable results with respect to biocompatibility, incorporation and remodeling. In the present pilot study we introduce a methodology to compare calcium phosphate-based bone grafting materials from world-leading companies in clinical trials and analyze them by means of established histology and synchrotron radiation-based micro computed tomography (SR$\mu$CT). The results indicate that the morphology of the bony structures depends on the selected bone grafting material and that an arbitrarily selected histological slice can lead to misleading conclusions. Complementary $\mu$CT data can become the basis for the identification of a representative slice. The registration of the selected histological slice with its counterpart in the three-dimensional $\mu$CT dataset was performed both visually and automatically with well comparable results. This registration allows for the compilation of a joint histogram to identify anatomical features, which can neither be extracted from histology nor from $\mu$CT data on their own. Accordingly, $\mu$CT will become an integral part of studies on the efficacy of bone augmentation materials and beyond. |
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700 | 1 | _ | |0 P:(DE-HGF)0 |a Chicherova, Natalia |b 2 |
700 | 1 | _ | |0 P:(DE-H253)PIP1007958 |a Deyhle, Hans |b 3 |
700 | 1 | _ | |0 P:(DE-H253)PIP1002967 |a Beckmann, Felix |b 4 |
700 | 1 | _ | |0 P:(DE-H253)PIP1008015 |a Müller, Bert |b 5 |e Corresponding author |
700 | 1 | _ | |0 P:(DE-H253)PIP1013288 |a Hieber, Simone |b 6 |
773 | _ | _ | |0 PERI:(DE-600)2128058-7 |a 10.3139/146.111050 |g Vol. 105, no. 7, p. 679 - 691 |n 7 |p 679 - 691 |t International journal of materials research |v 105 |x 2195-8556 |y 2014 |
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