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@ARTICLE{Stalder:192591,
      author       = {Stalder, Anja K. and Ilgenstein, Bernd and Chicherova,
                      Natalia and Deyhle, Hans and Beckmann, Felix and Müller,
                      Bert and Hieber, Simone},
      title        = {{C}ombined use of micro computed tomography and histology
                      to evaluate the regenerative capacity of bone grafting
                      materials},
      journal      = {International journal of materials research},
      volume       = {105},
      number       = {7},
      issn         = {2195-8556},
      address      = {München},
      publisher    = {Hanser},
      reportid     = {PUBDB-2014-04173},
      pages        = {679 - 691},
      year         = {2014},
      note         = {(c) Carl Hanser Verlag GmbH $\&$ Co. KG. Post referee
                      fulltext in progress.},
      abstract     = {Pre-clinical animal models are commonly used to evaluate
                      the osteogenic potential of bone grafting materials in-vivo.
                      Based on the histology analysis, the currently commercially
                      available bone grafting materials show comparable results
                      with respect to biocompatibility, incorporation and
                      remodeling. In the present pilot study we introduce a
                      methodology to compare calcium phosphate-based bone grafting
                      materials from world-leading companies in clinical trials
                      and analyze them by means of established histology and
                      synchrotron radiation-based micro computed tomography
                      (SR$\mu$CT). The results indicate that the morphology of the
                      bony structures depends on the selected bone grafting
                      material and that an arbitrarily selected histological slice
                      can lead to misleading conclusions. Complementary $\mu$CT
                      data can become the basis for the identification of a
                      representative slice. The registration of the selected
                      histological slice with its counterpart in the
                      three-dimensional $\mu$CT dataset was performed both
                      visually and automatically with well comparable results.
                      This registration allows for the compilation of a joint
                      histogram to identify anatomical features, which can neither
                      be extracted from histology nor from $\mu$CT data on their
                      own. Accordingly, $\mu$CT will become an integral part of
                      studies on the efficacy of bone augmentation materials and
                      beyond.},
      cin          = {DOOR / HZG},
      ddc          = {670},
      cid          = {I:(DE-H253)HAS-User-20120731 / I:(DE-H253)HZG-20120731},
      pnm          = {DORIS Beamline W2 (POF2-54G13) / DORIS Beamline BW2
                      (POF2-54G13)},
      pid          = {G:(DE-H253)POF2-W2-20130405 / G:(DE-H253)POF2-BW2-20130405},
      experiment   = {EXP:(DE-H253)D-W2-20150101 / EXP:(DE-H253)D-BW2-20150101},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000339328300010},
      doi          = {10.3139/146.111050},
      url          = {https://bib-pubdb1.desy.de/record/192591},
}