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@ARTICLE{PereiraLeite:167815,
      author       = {Pereira-Leite, Catarina and Carneiro, Cláudia and Soares,
                      José X. and Afonso, Carlos and Nunes, Cláudia and Lúcio,
                      Marlene and Reis, Salette},
      title        = {{B}iophysical characterization of the drug–membrane
                      interactions: {T}he case of propranolol and acebutolol},
      journal      = {European journal of pharmaceutics and biopharmaceutics},
      volume       = {84},
      number       = {1},
      issn         = {0939-6411},
      address      = {New York, NY [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DESY-2014-02141},
      pages        = {183 - 191},
      year         = {2013},
      abstract     = {The interaction of propranolol and acebutolol with
                      biological membranes was assessed in the present work by
                      using a range of biophysical techniques and liposomes, as
                      membrane mimetic models. Liposomes were made of zwitterionic
                      phosphatidylcholines and experiments were performed at
                      physiologic pH and at various membrane physical states (gel,
                      ripple and fluid phases). Fluorescence techniques were used
                      to study the partition coefficient of β-blockers, the
                      influence of drugs on membrane fluidity and the
                      drugs–membrane binding. Moreover, small and wide angle
                      X-ray scattering techniques were used to evaluate the
                      β-blockers effect on long range bilayer order and
                      hydrocarbon chain packing. The gathered results highlighted
                      the importance of electrostatic interactions between
                      propranolol and acebutolol with membranes. Furthermore, both
                      β-blockers exhibited a membrane-fluidizing effect and the
                      capacity to disturb the membrane organization. In general,
                      propranolol unveiled a more pronounced effect on membrane
                      fluidity and structure than acebutolol. In the current
                      study, the obtained results were also correlated with the
                      cardioprotective properties of the β-blockers studied.},
      cin          = {DOOR},
      ddc          = {610},
      cid          = {I:(DE-H253)HAS-User-20120731},
      pnm          = {FS Beamline without reference (POF2-544)},
      pid          = {G:(DE-H253)POF2-No-Ref-20130405},
      experiment   = {EXP:(DE-H253)Unknown-BL-20150101},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000319234600019},
      pubmed       = {pmid:23291047},
      doi          = {10.1016/j.ejpb.2012.12.005},
      url          = {https://bib-pubdb1.desy.de/record/167815},
}