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@ARTICLE{Dudutien:166502,
      author       = {Dudutienė, Virginija and Zubrienė, Asta and Smirnov,
                      Alexey and Gylytė, Joana and Timm, David and Manakova,
                      Elena and Gražulis, Saulius and Matulis, Daumantas},
      title        = {4-{S}ubstituted-2,3,5,6-tetrafluorobenzenesulfonamides as
                      inhibitors of carbonic anhydrases {I}, {II}, {VII}, {XII},
                      and {XIII}},
      journal      = {Bioorganic $\&$ medicinal chemistry},
      volume       = {21},
      number       = {7},
      issn         = {0968-0896},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DESY-2014-01384},
      pages        = {2093 - 2106},
      year         = {2013},
      note         = {© Elsevier Ltd. ; Post referee fulltext in progress;
                      Embargo 12 months from publication},
      abstract     = {A series of
                      4-substituted-2,3,5,6-tetrafluorobenezenesulfonamides were
                      synthesized and their binding potencies as inhibitors of
                      recombinant human carbonic anhydrase isozymes I, II, VII,
                      XII, and XIII were determined by the thermal shift assay,
                      isothermal titration calorimetry, and stop-flow CO2
                      hydration assay. All fluorinated benzenesulfonamides
                      exhibited nanomolar binding potency toward tested CAs and
                      fluorinated benzenesulfonamides posessed higher binding
                      potency than non-fluorinated compounds. The crystal
                      structures of
                      4-[(4,6-dimethylpyrimidin-2-yl)thio]-2,3,5,6-tetrafluorobenzenesulfonamide
                      in complex with CA II and CA XII, and
                      2,3,5,6-tetrafluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide
                      in complex with CA XIII were determined. The observed
                      dissociation constants for several fluorinated compounds
                      reached subnanomolar range for CA I isozyme. The affinity
                      and the selectivity of the compounds towards tested isozymes
                      are presented.},
      cin          = {EMBL-User},
      ddc          = {540},
      cid          = {I:(DE-H253)EMBL-User-20120814},
      pnm          = {DORIS Beamline K1.1 (POF2-54G13) / DORIS Beamline K1.3
                      (POF2-54G13)},
      pid          = {G:(DE-H253)POF2-K1.1-20130405 /
                      G:(DE-H253)POF2-K1.3-20130405},
      experiment   = {EXP:(DE-H253)D-K1.1-20150101 /
                      EXP:(DE-H253)D-K1.3-20150101},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000316770300052},
      pubmed       = {pmid:23394791},
      doi          = {10.1016/j.bmc.2013.01.008},
      url          = {https://bib-pubdb1.desy.de/record/166502},
}