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@ARTICLE{Cehlar:144121,
      author       = {Cehlar, O. and Skrabana, R. and Kovac, A. and Kovacech, B.
                      and Novak, M. and DESY},
      title        = {{C}rystallization and preliminary {X}-ray diffraction
                      analysis of tau protein microtubule-binding motifs in
                      complex with {T}au5 and {DC}25 antibody {F}ab fragments},
      journal      = {Acta crystallographica / F},
      volume       = {68},
      issn         = {1744-3091},
      address      = {Oxford [u.a.]},
      publisher    = {Blackwell},
      reportid     = {PHPPUBDB-25816},
      pages        = {1181},
      year         = {2012},
      abstract     = {The Alzheimer's disease-associated protein tau is an
                      intrinsically disordered protein with no preferred structure
                      in solution. Under physiological conditions, tau binds to
                      microtubules and regulates their dynamics, whereas during
                      the development of neurodegeneration tau dissociates from
                      microtubules, misfolds and creates highly insoluble
                      deposits. To elucidate the determinants of tau-protein
                      misfolding, tau peptides from microtubule-binding motifs
                      were crystallized in complexes with Fab fragments of
                      specific monoclonal antibodies. The crystals diffracted to
                      1.69 Å resolution and gave complete data sets using a
                      synchrotron X-ray source. Molecular replacement was used to
                      solve the phase problem.},
      keywords     = {Amino Acid Motifs / Antibodies, Monoclonal /
                      Crystallization / Crystallography, X-Ray / Immunoglobulin
                      Fab Fragments: chemistry / Immunoglobulin Fab Fragments:
                      immunology / Microtubules: chemistry / Microtubules:
                      metabolism / Protein Structure, Tertiary / tau Proteins:
                      chemistry / tau Proteins: immunology / tau Proteins:
                      metabolism / Antibodies, Monoclonal (NLM Chemicals) /
                      Immunoglobulin Fab Fragments (NLM Chemicals) / tau Proteins
                      (NLM Chemicals)},
      cin          = {HASYLAB},
      ddc          = {530},
      cid          = {$I:(DE-H253)HASYLAB_-2012_-20130307$},
      pnm          = {DORIS Beamline K1.2 (POF2-54G13)},
      pid          = {G:(DE-H253)POF2-K1.2-20130405},
      experiment   = {EXP:(DE-H253)D-K1.2-20150101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:23027743},
      pmc          = {pmc:PMC3497975},
      UT           = {WOS:000309357200008},
      doi          = {10.1107/S1744309112030382},
      url          = {https://bib-pubdb1.desy.de/record/144121},
}