000144121 001__ 144121
000144121 005__ 20250730162657.0
000144121 0247_ $$2pmid$$apmid:23027743
000144121 0247_ $$2pmc$$apmc:PMC3497975
000144121 0247_ $$2doi$$a10.1107/S1744309112030382
000144121 0247_ $$2ISSN$$a1744-3091
000144121 0247_ $$2WOS$$aWOS:000309357200008
000144121 0247_ $$2openalex$$aopenalex:W1999421400
000144121 037__ $$aPHPPUBDB-25816
000144121 041__ $$aeng
000144121 082__ $$a530
000144121 1001_ $$aCehlar, O.
000144121 1101_ $$aDESY$$bExperiments with synchrotron radiation
000144121 245__ $$aCrystallization and preliminary X-ray diffraction analysis of tau protein microtubule-binding motifs in complex with Tau5 and DC25 antibody Fab fragments
000144121 260__ $$aOxford [u.a.]$$bBlackwell$$c2012
000144121 300__ $$a1181
000144121 3367_ $$00$$2EndNote$$aJournal Article
000144121 3367_ $$2BibTeX$$aARTICLE
000144121 3367_ $$2DRIVER$$aarticle
000144121 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$mjournal
000144121 440_0 $$0PERI:(DE-600)2175956-X$$aActa Crystallogr.  F$$v68$$x1744-3091$$y10
000144121 500__ $$3Converted on 2013-05-30 10:01
000144121 500__ $$3Converted on 2013-06-21 19:21
000144121 520__ $$aThe Alzheimer's disease-associated protein tau is an intrinsically disordered protein with no preferred structure in solution. Under physiological conditions, tau binds to microtubules and regulates their dynamics, whereas during the development of neurodegeneration tau dissociates from microtubules, misfolds and creates highly insoluble deposits. To elucidate the determinants of tau-protein misfolding, tau peptides from microtubule-binding motifs were crystallized in complexes with Fab fragments of specific monoclonal antibodies. The crystals diffracted to 1.69 Å resolution and gave complete data sets using a synchrotron X-ray source. Molecular replacement was used to solve the phase problem.
000144121 536__ $$0G:(DE-H253)POF2-K1.2-20130405$$aDORIS Beamline K1.2 (POF2-54G13)$$cPOF2-54G13$$fPOF II$$x0
000144121 588__ $$aDataset connected to Pubmed
000144121 650_2 $$2MeSH$$aAmino Acid Motifs
000144121 650_2 $$2MeSH$$aAntibodies, Monoclonal
000144121 650_2 $$2MeSH$$aCrystallization
000144121 650_2 $$2MeSH$$aCrystallography, X-Ray
000144121 650_2 $$2MeSH$$aImmunoglobulin Fab Fragments: chemistry
000144121 650_2 $$2MeSH$$aImmunoglobulin Fab Fragments: immunology
000144121 650_2 $$2MeSH$$aMicrotubules: chemistry
000144121 650_2 $$2MeSH$$aMicrotubules: metabolism
000144121 650_2 $$2MeSH$$aProtein Structure, Tertiary
000144121 650_2 $$2MeSH$$atau Proteins: chemistry
000144121 650_2 $$2MeSH$$atau Proteins: immunology
000144121 650_2 $$2MeSH$$atau Proteins: metabolism
000144121 650_7 $$00$$2NLM Chemicals$$aAntibodies, Monoclonal
000144121 650_7 $$00$$2NLM Chemicals$$aImmunoglobulin Fab Fragments
000144121 650_7 $$00$$2NLM Chemicals$$atau Proteins
000144121 693__ $$0EXP:(DE-H253)D-K1.2-20150101$$1EXP:(DE-H253)DORISIII-20150101$$6EXP:(DE-H253)D-K1.2-20150101$$aDORIS III$$fDORIS Beamline K1.2$$x0
000144121 7001_ $$aSkrabana, R.
000144121 7001_ $$aKovac, A.
000144121 7001_ $$aKovacech, B.
000144121 7001_ $$aNovak, M.
000144121 773__ $$0PERI:(DE-600)2175956-X$$a10.1107/S1744309112030382$$gVol. 68, p. 1181$$p1181$$q68<1181$$tActa crystallographica / F$$v68$$x1744-3091$$y2012
000144121 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497975
000144121 909CO $$ooai:bib-pubdb1.desy.de:144121$$pVDB
000144121 9101_ $$0I:(DE-HGF)0$$aExternes Institut$$kExtern
000144121 9131_ $$0G:(DE-HGF)POF2-54G13$$1G:(DE-HGF)POF2-540$$2G:(DE-HGF)POF2-500$$3G:(DE-HGF)POF2$$4G:(DE-HGF)POF$$9G:(DE-H253)POF2-K1.2-20130405$$aDE-H253$$bStruktur der Materie$$lForschung mit Photonen, Neutronen, Ionen$$vDORIS III$$x0
000144121 9141_ $$y2012
000144121 915__ $$0StatID:(DE-HGF)0010$$aJCR/ISI refereed
000144121 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aMedline
000144121 915__ $$0StatID:(DE-HGF)1$$2StatID$$aNo Author Disambiguation
000144121 920_1 $$iExperiments with synchrotron radiation$$kHASYLAB
000144121 9201_ $$0I:(DE-H253)HASYLAB_-2012_-20130307$$kHASYLAB$$lExperiments with synchrotron radiation$$x0
000144121 920__ $$k001
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000144121 980__ $$ajournal
000144121 980__ $$aI:(DE-H253)HASYLAB_-2012_-20130307
000144121 980__ $$aConvertedRecord