%0 Journal Article
%A Al-Ebraheem, A.
%A Geraki, K.
%A Leek, R.
%A Harris, A. L.
%A Farquharson, M. J.
%A DESY
%T The Use of Bio-Metal Concentrations Correlated with Clinical Prognostic Factors to Assess Human Breast Tissues
%J X-ray spectrometry
%V 42
%N 4
%@ 0049-8246
%C New York, NY [u.a.]
%I Wiley
%M PHPPUBDB-25149
%P 330–336
%D 2013
%Z © John Wiley & Sons, Ltd.; Post referee fulltext in progress; Embargo 12 months from publication 
%X Worldwide, breast cancer is the most frequently diagnosed cancer in women and the leading cause of cancer death among women. The concentrations of bio-metals are crucial for the homeostasis of human health and are being shown to have significantly different concentrations when comparing human cancer tissue and normal tissue. This is the first study that correlates the findings of the differences in the levels of certain elements between individual tumours, to the clinical prognostic factors such as oestrogen receptor (ER) status, lymph node status, tumour size, grade, menopause status, human epidermal growth factor receptor 2 status, epidermal growth factor receptor status, relapsed status and survival status. Micro probe synchrotron radiation X-ray fluorescence techniques have been used to determine the localization and the relative concentrations of Zn, Cu, Fe and Ca in 128 formalin-fixed paraffin-embedded invasive ductal breast cancer (IDC) samples and normal surrounding breast tissue. The statistical analysis reveals a significant increase in the levels of Ca, Fe, Cu and Zn concentrations by 85
%F PUB:(DE-HGF)16
%9 Journal Article
%U <Go to ISI:>//WOS:000320727900026
%R 10.1002/xrs.2463
%U https://bib-pubdb1.desy.de/record/141084