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000140870 0247_ $$2pmid$$apmid:22575888
000140870 0247_ $$2pmc$$apmc:PMC3437443
000140870 0247_ $$2doi$$a10.1016/j.jmb.2012.04.031
000140870 0247_ $$2ISSN$$a1089-8638
000140870 0247_ $$2ISSN$$a0022-2836
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000140870 041__ $$aeng
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000140870 1001_ $$aWatson, A. A.
000140870 1101_ $$aDESY$$bEuropean Molecular Biology Laboratory
000140870 245__ $$aThe PHD and chromo domains regulate the ATPase activity of the human chromatin remodeler CHD4
000140870 260__ $$aAmsterdam [u.a.]$$bElsevier$$c2012
000140870 300__ $$a3-17
000140870 3367_ $$00$$2EndNote$$aJournal Article
000140870 3367_ $$2BibTeX$$aARTICLE
000140870 3367_ $$2DRIVER$$aarticle
000140870 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$mjournal
000140870 440_0 $$0PERI:(DE-600)1355192-9$$aJ. Mol. Biol.$$v422$$x0022-2836$$y1-2
000140870 500__ $$3Converted on 2013-05-30 09:49
000140870 500__ $$3Converted on 2013-06-21 19:21
000140870 520__ $$aThe NuRD (nucleosome remodeling and deacetylase) complex serves as a crucial epigenetic regulator of cell differentiation, proliferation, and hematopoietic development by coupling the deacetylation and demethylation of histones, nucleosome mobilization, and the recruitment of transcription factors. The core nucleosome remodeling function of the mammalian NuRD complex is executed by the helicase-domain-containing ATPase CHD4 (Mi-2β) subunit, which also contains N-terminal plant homeodomain (PHD) and chromo domains. The mode of regulation of chromatin remodeling by CHD4 is not well understood, nor is the role of its PHD and chromo domains. Here, we use small-angle X-ray scattering, nucleosome binding ATPase and remodeling assays, limited proteolysis, cross-linking, and tandem mass spectrometry to propose a three-dimensional structural model describing the overall shape and domain interactions of CHD4 and discuss the relevance of these for regulating the remodeling of chromatin by the NuRD complex.
000140870 536__ $$0G:(DE-H253)POF2-D1.2-20130405$$aDORIS Beamline D1.2 (POF2-54G13)$$cPOF2-54G13$$fPOF II$$x0
000140870 588__ $$aDataset connected to Pubmed
000140870 650_2 $$2MeSH$$aAdenosine Triphosphatases: metabolism
000140870 650_2 $$2MeSH$$aAutoantigens: chemistry
000140870 650_2 $$2MeSH$$aAutoantigens: metabolism
000140870 650_2 $$2MeSH$$aBinding Sites
000140870 650_2 $$2MeSH$$aChromatin: metabolism
000140870 650_2 $$2MeSH$$aChromatin Assembly and Disassembly
000140870 650_2 $$2MeSH$$aElectrophoretic Mobility Shift Assay
000140870 650_2 $$2MeSH$$aHumans
000140870 650_2 $$2MeSH$$aMi-2 Nucleosome Remodeling and Deacetylase Complex: chemistry
000140870 650_2 $$2MeSH$$aMi-2 Nucleosome Remodeling and Deacetylase Complex: metabolism
000140870 650_2 $$2MeSH$$aModels, Biological
000140870 650_2 $$2MeSH$$aNucleosomes: metabolism
000140870 650_2 $$2MeSH$$aProtein Structure, Tertiary
000140870 650_2 $$2MeSH$$aProteolysis
000140870 650_7 $$00$$2NLM Chemicals$$aAutoantigens
000140870 650_7 $$00$$2NLM Chemicals$$aCHD4 protein, human
000140870 650_7 $$00$$2NLM Chemicals$$aChromatin
000140870 650_7 $$00$$2NLM Chemicals$$aNucleosomes
000140870 650_7 $$0EC 3.5.1.98$$2NLM Chemicals$$aMi-2 Nucleosome Remodeling and Deacetylase Complex
000140870 650_7 $$0EC 3.6.1.-$$2NLM Chemicals$$aAdenosine Triphosphatases
000140870 693__ $$0EXP:(DE-H253)D-D1.2-20150101$$1EXP:(DE-H253)DORISIII-20150101$$6EXP:(DE-H253)D-D1.2-20150101$$aDORIS III$$fDORIS Beamline D1.2$$x0
000140870 7001_ $$aMahajan, P.
000140870 7001_ $$aMertens, H. D.
000140870 7001_ $$aDeery, M. J.
000140870 7001_ $$aZhang, W.
000140870 7001_ $$aPham, P.
000140870 7001_ $$aDu, X.
000140870 7001_ $$aBartke, T.
000140870 7001_ $$aEdlich, C.
000140870 7001_ $$aBerridge, G.
000140870 7001_ $$aChen, Y.
000140870 7001_ $$aBurgess-Brown, N. A.
000140870 7001_ $$aKouzarides, T.
000140870 7001_ $$aWiechens, N.
000140870 7001_ $$aOwen-Hughes, T.
000140870 7001_ $$aSvergun, D. I.
000140870 7001_ $$aGileadi, O.
000140870 7001_ $$aLaue, E. D.
000140870 773__ $$0PERI:(DE-600)1355192-9$$a10.1016/j.jmb.2012.04.031$$gVol. 422, p. 3-17$$p3-17$$q422<3-17$$tJournal of molecular biology$$v422$$x0022-2836$$y2012
000140870 85640 $$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437443/
000140870 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437443
000140870 909CO $$ooai:bib-pubdb1.desy.de:140870$$pVDB
000140870 9101_ $$0I:(DE-HGF)0$$aExternes Institut$$kExtern
000140870 9131_ $$0G:(DE-HGF)POF2-54G13$$1G:(DE-HGF)POF2-540$$2G:(DE-HGF)POF2-500$$3G:(DE-HGF)POF2$$4G:(DE-HGF)POF$$9G:(DE-H253)POF2-D1.2-20130405$$aDE-H253$$bStruktur der Materie$$lForschung mit Photonen, Neutronen, Ionen$$vDORIS III$$x0
000140870 9141_ $$a(c) Elsevier. Code P. Bitte nach post referee recherchieren.$$y2012
000140870 915__ $$0StatID:(DE-HGF)0010$$aJCR/ISI refereed
000140870 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aMedline
000140870 915__ $$0StatID:(DE-HGF)1$$2StatID$$aNo Author Disambiguation
000140870 920_1 $$iEuropean Molecular Biology Laboratory$$kEMBL
000140870 9201_ $$0I:(DE-H253)EMBL_-2012_-20130307$$kEMBL$$lEuropean Molecular Biology Laboratory$$x0
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000140870 980__ $$aConvertedRecord