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2020-10-22
14:20
OpenAccess [PUBDB-2020-03977] Report

Sachbericht 2019 [VH-NG-1404]
[2019]
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2020-10-21
15:32
OpenAccess [PUBDB-2020-03957] Journal Article
et al
Search for Axionlike Particles Produced in $e^ + e^−$ Collisions at Belle II
[Belle II Preprint 2020-001; KEK Preprint 2020-10; arXiv:2007.13071]
We present a search for the direct production of a light pseudoscalar $a$ decaying into two photons with the Belle II detector at the SuperKEKB collider. We search for the process ${e^+e^-\to\gamma a, a \to\gamma\gamma}$ in the mass range ${0.2} \,< m_a < {9.7}\,{\text{GeV/$c$}^2}$ using data corresponding to an integrated luminosity of $(445\pm 3)\,\text{pb}^{-1}$. [...]
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ddc:530

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2020-10-21
14:58
OpenAccess [PUBDB-2020-03954] Journal Article
et al
Measurement of the charm-mixing parameter $y_{CP}$ in $D^{0}\to K^{0}_{S}\omega$ decays at Belle
[Belle Preprint 2019-22; KEK Preprint 2019-52; arXiv:1912.10912]
We report the first measurement of the charm-mixing parameter $y_{CP}$ in $D^{0}$ decays to the $CP$-odd final state $K^{0}_{S}\omega$. The study uses the full Belle $e^{+}e^-$ annihilation data sample of $976\rm~ fb^{-1}$ taken at or near the $\Upsilon(4S)$ centre-of-mass energy. [...]
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ddc:530

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2020-10-21
13:22
[PUBDB-2020-03953] Conference Presentation

Summary of current CMS efforts in EFT
1st open meeting of the LHC EFT Working Group, LHC-EFT1, Video onlyVideo only, Virtual World, 19 Oct 2020 - 20 Oct 20202020-10-192020-10-20
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2020-10-21
13:17
[PUBDB-2020-03952] Conference Presentation

Measuring standard model parameters with top-quark cross sections
13th International Workshop on Top-Quark Physics, TOP2020, CERNONLINE, CERN, Virtual World, 13 Sep 2020 - 18 Sep 20202020-09-132020-09-18
Precise top quark cross section measurements (inclusive and differential) from ATLAS and CMS are confronted with recent theory calculations to extract parameters of the SM, such as the top quark mass and the top quark Yukawa coupling, and also constrain parton distribution functions. The presentation is expected to cover in part theoretical considerations necessary particularly at high precision
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2020-10-21
12:24
[PUBDB-2020-03951] Journal Article
et al
MAP Kinase-Mediated Activation of RSK1 and MK2 Substrate Kinases
Structure 28(10), 1101 - 1113.e5 () [10.1016/j.str.2020.06.007]  GO
Mitogen-activated protein kinases (MAPKs) control essential eukaryotic signaling pathways. While much has been learned about MAPK activation, much less is known about substrate recruitment and specificity [...]
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ddc:540

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2020-10-21
10:52
OpenAccess [PUBDB-2020-03946] Journal Article
et al
Rational design of balanced dual-targeting antibiotics with limited resistance
PLoS biology 18(10), e3000819 (1-31) - () [10.1371/journal.pbio.3000819]  GO
Antibiotics that inhibit multiple bacterial targets offer a promising therapeutic strategy against resistance evolution, but developing such antibiotics is challenging. Here we demonstrate that a rational design of balanced multitargeting antibiotics is feasible by using a medicinal chemistry workflow [...]
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ddc:610

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2020-10-21
10:46
[PUBDB-2020-03944] Journal Article
et al
Isoform-Selective Enzyme Inhibitors by Exploring Pocket Size According to the Lock-and-Key Principle
Biophysical journal 119(8), 1513 - 1524 () [10.1016/j.bpj.2020.08.037]  GO
In the design of high-affinity and enzyme isoform-selective inhibitors, we applied an approach of augmenting the substituents attached to the benzenesulfonamide scaffold in three ways, namely, substitutions at the 3,5- or 2,4,6-positions or expansion of the condensed ring system. The increased size of the substituents determined the spatial limitations of the active sites of the 12 catalytically active human carbonic anhydrase (CA) isoforms until no binding was observed because of the inability of the compounds to fit in the active site [...]
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ddc:570

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2020-10-21
10:42
OpenAccess [PUBDB-2020-03943] Journal Article
et al
High-resolution crystal structure and biochemical characterization of a GH11 endoxylanase from Nectria haematococca
Scientific reports 10(1), 15658 (1-13) () [10.1038/s41598-020-72644-w]  GO
Enzymatic degradation of vegetal biomass offers versatile procedures to improve the production of alternative fuels and other biomass-based products. Here we present the three-dimensional structure of a xylanase from Nectria haematococca (NhGH11) at 1.0 Å resolution and its functional properties [...]
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ddc:600

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2020-10-21
10:21
OpenAccess [PUBDB-2020-03942] Journal Article
et al
Structural and mechanistic basis of capsule O-acetylation in Neisseria meningitidis serogroup A
Nature Communications 11(1), 4723 (1-12) () [10.1038/s41467-020-18464-y]  GO
$O$-Acetylation of the capsular polysaccharide (CPS) of Neisseria meningitidis serogroup A (NmA) is critical for the induction of functional immune responses, making this modification mandatory for CPS-based anti-NmA vaccines. Using comprehensive NMR studies, we demonstrate that $O$-acetylation stabilizes the labile anomeric phosphodiester-linkages of the NmA-CPS and occurs in position C3 and C4 of the $N$-acetylmannosamine units due to enzymatic transfer and non-enzymatic ester migration, respectively [...]
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ddc:500

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