TY  - JOUR
AU  - Majewski, J.
AU  - Stec, B.
AU  - DESY
TI  - X-ray scattering studies of model lipid membrane interacting with purothionin provide support for a previously proposed mechanism of membrane lysis
JO  - European biophysics journal
VL  - 39
SN  - 0175-7571
CY  - Berlin
PB  - Springer
M1  - PHPPUBDB-16564
SP  - 1155
PY  - 2009
N1  - (c) European Biophysical Societies’ Association ; Post referee fulltext in progress 2; Embargo 12 months from publication
AB  - Thionins, ubiquitous plant toxins, are believed to act by lysing the membrane of pathogenic organisms. Several competing mechanisms were proposed for the lysis of phospholipid membranes by the toxins. In order to study in more detail the proposed mechanisms and possibly resolve among the competing proposals, the interactions of purothionins with a model lipid membrane in the form of a monolayer were studied. The monolayer formed at the air-water interface was studied by synchrotron X-ray reflectivity and grazing incidents diffraction methods. The model membrane was composed of 90:10 mol
KW  - 1,2-Dipalmitoylphosphatidylcholine: chemistry
KW  - Air
KW  - Antimicrobial Cationic Peptides: chemistry
KW  - Cell Membrane: chemistry
KW  - Cell Membrane: physiology
KW  - Electrons
KW  - Kinetics
KW  - Membranes, Artificial
KW  - Models, Chemical
KW  - Phosphatidylserines: chemistry
KW  - Phospholipids: chemistry
KW  - Plant Proteins: chemistry
KW  - Scattering, Radiation
KW  - Synchrotrons
KW  - Unilamellar Liposomes: chemistry
KW  - Water
KW  - X-Ray Diffraction
KW  - X-Rays
KW  - Antimicrobial Cationic Peptides (NLM Chemicals)
KW  - Membranes, Artificial (NLM Chemicals)
KW  - Phosphatidylserines (NLM Chemicals)
KW  - Phospholipids (NLM Chemicals)
KW  - Plant Proteins (NLM Chemicals)
KW  - Unilamellar Liposomes (NLM Chemicals)
KW  - 1,2-Dipalmitoylphosphatidylcholine (NLM Chemicals)
KW  - dipalmitoylphosphatidylserine (NLM Chemicals)
KW  - Water (NLM Chemicals)
KW  - purothionin (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:19997910
UR  - <Go to ISI:>//WOS:000279194500005
DO  - DOI:10.1007/s00249-009-0568-0
UR  - https://bib-pubdb1.desy.de/record/89041
ER  -