%0 Journal Article
%A Majewski, J.
%A Stec, B.
%A DESY
%T X-ray scattering studies of model lipid membrane interacting with purothionin provide support for a previously proposed mechanism of membrane lysis
%J European biophysics journal
%V 39
%@ 0175-7571
%C Berlin
%I Springer
%M PHPPUBDB-16564
%P 1155
%D 2009
%Z (c) European Biophysical Societies’ Association ; Post referee fulltext in progress 2; Embargo 12 months from publication
%X Thionins, ubiquitous plant toxins, are believed to act by lysing the membrane of pathogenic organisms. Several competing mechanisms were proposed for the lysis of phospholipid membranes by the toxins. In order to study in more detail the proposed mechanisms and possibly resolve among the competing proposals, the interactions of purothionins with a model lipid membrane in the form of a monolayer were studied. The monolayer formed at the air-water interface was studied by synchrotron X-ray reflectivity and grazing incidents diffraction methods. The model membrane was composed of 90:10 mol
%K 1,2-Dipalmitoylphosphatidylcholine: chemistry
%K Air
%K Antimicrobial Cationic Peptides: chemistry
%K Cell Membrane: chemistry
%K Cell Membrane: physiology
%K Electrons
%K Kinetics
%K Membranes, Artificial
%K Models, Chemical
%K Phosphatidylserines: chemistry
%K Phospholipids: chemistry
%K Plant Proteins: chemistry
%K Scattering, Radiation
%K Synchrotrons
%K Unilamellar Liposomes: chemistry
%K Water
%K X-Ray Diffraction
%K X-Rays
%K Antimicrobial Cationic Peptides (NLM Chemicals)
%K Membranes, Artificial (NLM Chemicals)
%K Phosphatidylserines (NLM Chemicals)
%K Phospholipids (NLM Chemicals)
%K Plant Proteins (NLM Chemicals)
%K Unilamellar Liposomes (NLM Chemicals)
%K 1,2-Dipalmitoylphosphatidylcholine (NLM Chemicals)
%K dipalmitoylphosphatidylserine (NLM Chemicals)
%K Water (NLM Chemicals)
%K purothionin (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:19997910
%U <Go to ISI:>//WOS:000279194500005
%R 10.1007/s00249-009-0568-0
%U https://bib-pubdb1.desy.de/record/89041