% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Tielemans:644930,
      author       = {Tielemans, Birger and Llambrich, Sergi and Seldeslachts,
                      Laura and Cremer, Jonathan and Tsui, Hung Chang and
                      Jonckheere, Anne-Charlotte and Marain, Nora Fopke and
                      Riedel, Mirko and Wouters, Jens and Herzen, Julia and
                      Leszczyński, Bartosz and Verbeken, Erik and Vanoirbeek,
                      Jeroen and Vande Velde, Greetje},
      title        = {{C}ardiopulmonary and {I}mmune {A}lterations in the
                      {T}s65{D}n {M}ouse {M}odel of {D}own {S}yndrome and
                      {M}odulation by {E}pigallocatechin-3-{G}allate-{E}nriched
                      {G}reen {T}ea {E}xtract},
      journal      = {Pharmaceutics},
      volume       = {17},
      number       = {11},
      issn         = {1999-4923},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {PUBDB-2026-00473},
      pages        = {1366},
      year         = {2025},
      abstract     = {Background/Objectives: Cardiovascular and pulmonary
                      diseases are leading comorbidities n individuals with Down
                      syndrome (DS). Although clinically well described,
                      preclinical models fully characterizing these
                      cardiopulmonary alterations are lacking. Our objective is to
                      characterize the cardiopulmonary and immunological phenotype
                      in a commonly used DS mouse model, the Ts65Dn mice, and
                      investigate the modulatory effects of green tea extract
                      enriched in epigallocatechin-3-gallate (GTE-EGCG); Methods:
                      Treatment started at embryonic day 9 and continued until
                      postnatal day (PD) 180. Mice were longitudinally monitored
                      using micro-computed tomography, and structural, functional,
                      and immunological alterations were evaluated at PD210 to
                      determine the persistent effects of GTE-EGCG administration;
                      Results: Ts65Dn mice displayed normal structural lung
                      development and presented with right ventricular hypertrophy
                      and reduced B-cell lymphocytes, indicating that this model
                      may find applications in immunological respiratory research
                      specific to the context of DS. GTE-EGCG administration
                      induced transient lung immaturity, persistent decreases in
                      lung function, and airway hyperreactivity, while normalizing
                      arterial and right ventricular morphology and partially
                      restoring B-cell lymphocyte numbers; Conclusions: These
                      findings underscore the dual nature of EGCG modulation, both
                      beneficial and adverse, and highlight the importance of a
                      multiorgan, holistic approach when evaluating therapeutic
                      interventions in DS models.Keywords:Down syndrome; Ts65Dn
                      mouse model; heart and lung development; modulation by green
                      tea extract enriched in epigallocatechin-3-gallate;
                      cardiovascular and immune alterations},
      cin          = {DOOR ; HAS-User / Hereon},
      ddc          = {610},
      cid          = {I:(DE-H253)HAS-User-20120731 / I:(DE-H253)Hereon-20210428},
      pnm          = {6G3 - PETRA III (DESY) (POF4-6G3)},
      pid          = {G:(DE-HGF)POF4-6G3},
      experiment   = {EXP:(DE-H253)P-P05-20150101},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.3390/pharmaceutics17111366},
      url          = {https://bib-pubdb1.desy.de/record/644930},
}