%0 Journal Article
%A Tielemans, Birger
%A Llambrich, Sergi
%A Seldeslachts, Laura
%A Cremer, Jonathan
%A Tsui, Hung Chang
%A Jonckheere, Anne-Charlotte
%A Marain, Nora Fopke
%A Riedel, Mirko
%A Wouters, Jens
%A Herzen, Julia
%A Leszczyński, Bartosz
%A Verbeken, Erik
%A Vanoirbeek, Jeroen
%A Vande Velde, Greetje
%T Cardiopulmonary and Immune Alterations in the Ts65Dn Mouse Model of Down Syndrome and Modulation by Epigallocatechin-3-Gallate-Enriched Green Tea Extract
%J Pharmaceutics
%V 17
%N 11
%@ 1999-4923
%C Basel
%I MDPI
%M PUBDB-2026-00473
%P 1366 
%D 2025
%X Background/Objectives: Cardiovascular and pulmonary diseases are leading comorbidities n individuals with Down syndrome (DS). Although clinically well described, preclinical models fully characterizing these cardiopulmonary alterations are lacking. Our objective is to characterize the cardiopulmonary and immunological phenotype in a commonly used DS mouse model, the Ts65Dn mice, and investigate the modulatory effects of green tea extract enriched in epigallocatechin-3-gallate (GTE-EGCG); Methods: Treatment started at embryonic day 9 and continued until postnatal day (PD) 180. Mice were longitudinally monitored using micro-computed tomography, and structural, functional, and immunological alterations were evaluated at PD210 to determine the persistent effects of GTE-EGCG administration; Results: Ts65Dn mice displayed normal structural lung development and presented with right ventricular hypertrophy and reduced B-cell lymphocytes, indicating that this model may find applications in immunological respiratory research specific to the context of DS. GTE-EGCG administration induced transient lung immaturity, persistent decreases in lung function, and airway hyperreactivity, while normalizing arterial and right ventricular morphology and partially restoring B-cell lymphocyte numbers; Conclusions: These findings underscore the dual nature of EGCG modulation, both beneficial and adverse, and highlight the importance of a multiorgan, holistic approach when evaluating therapeutic interventions in DS models.Keywords:Down syndrome; Ts65Dn mouse model; heart and lung development; modulation by green tea extract enriched in epigallocatechin-3-gallate; cardiovascular and immune alterations 
%F PUB:(DE-HGF)16
%9 Journal Article
%R 10.3390/pharmaceutics17111366
%U https://bib-pubdb1.desy.de/record/644930