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@ARTICLE{Genz:639214,
      author       = {Genz, Luca and Nair, Sanjana and Sweeney, Aaron and Topf,
                      Maya},
      title        = {{D}rug targeting of protein-nucleic acid interactions},
      journal      = {Current opinion in structural biology},
      volume       = {95},
      issn         = {0959-440X},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {PUBDB-2025-04336},
      pages        = {103165},
      year         = {2025},
      note         = {and DFG CRC1648},
      abstract     = {Protein–nucleic acid interactions are vital to gene
                      regulation and disease, yet have long been considered
                      “undruggable.” Recent advances are reshaping this
                      paradigm, enabling therapeutic targeting of DNA- and
                      RNA-binding proteins. In this review, we highlight four
                      major strategies: (1) direct disruption of protein-nucleic
                      acid binding, (2) stabilization of specific complexes or
                      conformations, (3) targeted degradation of interaction
                      partners, and (4) allosteric modulation. We explore key
                      examples across transcription factors, RNA-binding proteins,
                      and DNA repair proteins, and emphasize emerging chemical,
                      structural, and computational techniques that are
                      accelerating discovery. Together, by intervening directly in
                      the gene regulatory machinery, these approaches expand the
                      druggable genome and open new avenues for treating cancer,
                      genetic disorders, and viral infections.},
      cin          = {CSSB-LIV/UKE-MT},
      ddc          = {570},
      cid          = {$I:(DE-H253)CSSB-LIV_UKE-MT-20220525$},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      experiment   = {EXP:(DE-MLZ)NOSPEC-20140101},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1016/j.sbi.2025.103165},
      url          = {https://bib-pubdb1.desy.de/record/639214},
}