%0 Journal Article
%A Steinbrueck, Axel
%A Reback, Matthew L.
%A Rumancev, Christoph
%A Siegmund, Daniel
%A Garrevoet, Jan
%A Falkenberg, Gerald
%A Rosenhahn, Axel
%A Prokop, Aram
%A Metzler-Nolte, Nils
%T Quinizarin Gold(I) N‐Heterocyclic Carbene Complexes with Synergistic Activity Against Anthracycline‐Resistant Leukaemia Cells: Synthesis and Biological Activity Studies
%J Chemistry - a European journal
%V 31
%N 11
%@ 0947-6539
%C Weinheim
%I Wiley-VCH
%M PUBDB-2025-01683
%P e202404147
%D 2025
%X New, asymmetric quinizarin-Au(I)-NHC complexes were designed, isolated, and fully characterised including by single crystal X-ray crystallography. Cytotoxicity studies showed effective growth inhibition in HeLa cervical cancer cells with IC<sub>50</sub> values ranging from 2.4 μM to 5.3 μM. The successful cellular uptake was evidenced by X-ray fluorescence imaging on cryo-preserved whole HeLa cells and the sub-cellular localisation was monitored by live-cell fluorescence microscopy. Notably, complex 2 b showed circumvention of acquired anthracycline resistance in K562 leukaemia cells as well as synergistic activity with doxorubicin against both wild-type and anthracycline-resistant Nalm-6 leukaemia cells. Interestingly, sub-cellular localisation towards mitochondria proved to be more important than the compounds’ overall cytotoxicity for potent antiproliferative activity and to achieve effective resistance circumvention. 
%B XXIX. International Conference on Coordination and Bioinorganic Chemistry
%C , Bratislava (Slovakia)
M2 Bratislava, Slovakia
%F PUB:(DE-HGF)8 ; PUB:(DE-HGF)16
%9 Contribution to a conference proceedingsJournal Article
%$ pmid:39757433
%U <Go to ISI:>//WOS:001389875200001
%R 10.1002/chem.202404147
%U https://bib-pubdb1.desy.de/record/627908