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@ARTICLE{Zhu:627276,
      author       = {Zhu, Dingcheng and Brückner, Dennis and Sosniok, Martin
                      and Skiba, Marvin and Feliu, Neus and Gallego, Marta and
                      Liu, Yang and Schulz, Florian and Falkenberg, Gerald and
                      Parak, Wolfgang J. and Sanchez-Cano, Carlos},
      title        = {{S}ize-dependent penetration depth of colloidal
                      nanoparticles into cell spheroids},
      journal      = {Advanced drug delivery reviews},
      volume       = {222},
      issn         = {0169-409X},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {PUBDB-2025-01593},
      pages        = {115593},
      year         = {2025},
      abstract     = {The penetration of nanoparticle (NP)-based drugs into
                      tissue is essential for their use as nanomedicines.
                      Systematic studies about how different NP properties, such
                      as size, influence NP penetration are helpful for the
                      development of NP-based drugs. An overview of how NPs of
                      different sizes may penetrate three-dimensional cell
                      spheroids is given. In particular different techniques for
                      experimental analysis are compared, including mass
                      spectrometry, flow cytometry, optical fluorescence
                      microscopy, X-ray fluorescence microscopy, and transmission
                      electron microscopy. An experimental data set is
                      supplemented exclusively made for this review, in which the
                      results of different techniques are visualized. Limitations
                      of the analysis techniques for different types of NPs,
                      including carbon-based materials, are discussed.},
      cin          = {FS-PETRA-S / DOOR ; HAS-User},
      ddc          = {610},
      cid          = {I:(DE-H253)FS-PETRA-S-20210408 /
                      I:(DE-H253)HAS-User-20120731},
      pnm          = {633 - Life Sciences – Building Blocks of Life: Structure
                      and Function (POF4-633) / 6G3 - PETRA III (DESY) (POF4-6G3)
                      / FS-Proposal: I-20191151 EC (I-20191151-EC)},
      pid          = {G:(DE-HGF)POF4-633 / G:(DE-HGF)POF4-6G3 /
                      G:(DE-H253)I-20191151-EC},
      experiment   = {EXP:(DE-H253)P-P06-20150101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40339992},
      UT           = {WOS:001490757500001},
      doi          = {10.1016/j.addr.2025.115593},
      url          = {https://bib-pubdb1.desy.de/record/627276},
}