TY  - JOUR
AU  - Zhu, Dingcheng
AU  - Brückner, Dennis
AU  - Sosniok, Martin
AU  - Skiba, Marvin
AU  - Feliu, Neus
AU  - Gallego, Marta
AU  - Liu, Yang
AU  - Schulz, Florian
AU  - Falkenberg, Gerald
AU  - Parak, Wolfgang J.
AU  - Sanchez-Cano, Carlos
TI  - Size-dependent penetration depth of colloidal nanoparticles into cell spheroids
JO  - Advanced drug delivery reviews
VL  - 222
SN  - 0169-409X
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - PUBDB-2025-01593
SP  - 115593
PY  - 2025
AB  - The penetration of nanoparticle (NP)-based drugs into tissue is essential for their use as nanomedicines. Systematic studies about how different NP properties, such as size, influence NP penetration are helpful for the development of NP-based drugs. An overview of how NPs of different sizes may penetrate three-dimensional cell spheroids is given. In particular different techniques for experimental analysis are compared, including mass spectrometry, flow cytometry, optical fluorescence microscopy, X-ray fluorescence microscopy, and transmission electron microscopy. An experimental data set is supplemented exclusively made for this review, in which the results of different techniques are visualized. Limitations of the analysis techniques for different types of NPs, including carbon-based materials, are discussed.
LB  - PUB:(DE-HGF)16
C6  - pmid:40339992
UR  - <Go to ISI:>//WOS:001490757500001
DO  - DOI:10.1016/j.addr.2025.115593
UR  - https://bib-pubdb1.desy.de/record/627276
ER  -