Journal Article

PUBDB-2025-01593

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Size-dependent penetration depth of colloidal nanoparticles into cell spheroids

Zhu, D.Extern* ; Brückner, D.DESY* ; Sosniok, M.Extern* ; Skiba, M.Extern* ; Feliu, N.Extern* ; Gallego, M. ; Liu, Y. ; Schulz, F.Extern* ; Falkenberg, G. (Corresponding author)DESY* ; Parak, W. J. (Corresponding author)Extern* ; Sanchez-Cano, C. (Corresponding author)

2025
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.addr.2025.115593  doi:10.3204/PUBDB-2025-01593

Abstract: The penetration of nanoparticle (NP)-based drugs into tissue is essential for their use as nanomedicines. Systematic studies about how different NP properties, such as size, influence NP penetration are helpful for the development of NP-based drugs. An overview of how NPs of different sizes may penetrate three-dimensional cell spheroids is given. In particular different techniques for experimental analysis are compared, including mass spectrometry, flow cytometry, optical fluorescence microscopy, X-ray fluorescence microscopy, and transmission electron microscopy. An experimental data set is supplemented exclusively made for this review, in which the results of different techniques are visualized. Limitations of the analysis techniques for different types of NPs, including carbon-based materials, are discussed.

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Contributing Institute(s):

1. PETRA-S (FS-PETRA-S)
2. DOOR-User (DOOR ; HAS-User)

Research Program(s):

1. 633 - Life Sciences – Building Blocks of Life: Structure and Function (POF4-633) (POF4-633)
2. 6G3 - PETRA III (DESY) (POF4-6G3) (POF4-6G3)
3. FS-Proposal: I-20191151 EC (I-20191151-EC) (I-20191151-EC)

Experiment(s):

1. PETRA Beamline P06 (PETRA III)

Appears in the scientific report 2025

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Database coverage:
; ; ; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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