guest ::
| Home > Authorities > Grants > Record #556682 |
DFG project G:(GEPRIS)138669277
Role of NF-kB in glomerulonephritis
| Coordinator | Professor Dr. Friedrich Thaiss |
| Grant period | 2009 - 2016 |
| Funding body | Deutsche Forschungsgemeinschaft |
| DFG | |
| Identifier | G:(GEPRIS)138669277 |
⇧ KFO 228: Immunopathogenesis and Therapy of Glomerulonephritis ⇧
Note: Activation of the transcription factor NF-κB plays a pivotal role in inflammatory diseases by regulation of key mediators such as cytokines and chemokines. The central kinases in the multistep activation process of NF-κB are IKK2 (or IKKβ) and IKK1 (or IKKα). These kinases are therefore promising targets for pharmacological inhibition of NF-κB activation. IKK1 and IKK2 are dynamically activated and inactivated in the course of inflammation. Furthermore, they are differentially regulated in a cell lineage-specific manner. This project will concentrate on the analysis of cell-specific and time-dependent activation of NF-κB by IKK1 and IKK2 in an experimental model of crescentic glomerulonephritis. Understanding of the mechanisms that are relevant in differential activation of NF-κB in cell lineage specific leukocytes as well as in resident renal cells might be of great importance for future therapeutic strategies in patients with rapidly progressive glomerulonephritis.