Record #523886

DFG project G:(GEPRIS)222858180

The molecular identity, function, and epilepsy-related plasticity of voltage- and calcium-dependent potassium channels in dentate gyrus granule cells of mice and humans.

Coordinator	Dr. Jakob Wolfart
Grant period	2012 - 2017
Funding body	Deutsche Forschungsgemeinschaft
	DFG
Identifier	G:(GEPRIS)222858180

Note: We will determine the molecular identity, function, and epilepsy-related plasticity of voltage- and calcium-dependent potassium channels of dentate gyrus granule cells. To this end we will use electrophysiological and molecular biology techniques. Hippocampal tissue of humans obtained during epilepsy surgery and epilepsy animal models will be employed. Using conductance-based computer simulations, we will precisely dissect the functional impact of identified potassium channels under physiological and pathophysiological conditions.

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Record created 2023-02-02, last modified 2024-09-27

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