DFG project G:(GEPRIS)141539087
Der Einfluss des Hepatitis C Virus auf humane B-Zelen und die Rolle von HCV auf B-Zell-lymphoproliferative Erkrankungen (A02)
| Coordinator | Professor Dr. Jan Dürig ; Professor Dr. Ralf Küppers |
| Grant period | 2009 - 2017 |
| Funding body | Deutsche Forschungsgemeinschaft |
| | DFG |
| Identifier | G:(GEPRIS)141539087 |
⇧ TRR 60: Interaktion von Viren mit Zellen des Immunsystems bei persistierenden Virusinfektionen: Grundlagen für Immuntherapie und Impfungen ⇧
Note: As a first aim, we want to characterize the occurrence and characteristics of monoclonal B cell expansions in HCV patients (monoclonal B cell lymphocytosis (MBL) and mixed cryoblobulinema) without lymphomas. This includes determination of the specific B cell subsets that give rise to MBL and determination by deep sequencing of isolated clones whether they already carry genetic lesions and hence represent pre-malignant B cells. Secondly, we aim to determine the landscape of somatic mutations in HCV-associated B cell lymphomas to clarify whether such tumors have a specific, HCV-related pathogenesis. Thirdly, we will study the direct influences of HCV on B cells in culture in terms of signaling pathway activations and altered gene expression to reveal the mechanisms by which HCV affects B cell fate and physiology.
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