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@ARTICLE{Janisova:449052,
      author       = {Janisova, Larisa and Gruzinov, Andrey and Zaborova, Olga V.
                      and Velychkivska, Nadiia and Vaněk, Ondřej and Chytil,
                      Petr and Etrych, Tomáš and Janoušková, Olga and Zhang,
                      Xiaohan and Blanchet, Clement and Papadakis, Christine M.
                      and Svergun, Dmitri I. and Filippov, Sergey K.},
      title        = {{M}olecular {M}echanisms of the {I}nteractions of
                      {N}-(2-{H}ydroxypropyl)methacrylamide {C}opolymers
                      {D}esigned for {C}ancer {T}herapy with {B}lood {P}lasma
                      {P}roteins},
      journal      = {Pharmaceutics},
      volume       = {12},
      number       = {2},
      issn         = {1999-4923},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {PUBDB-2020-03577},
      pages        = {1-9},
      year         = {2020},
      abstract     = {The binding of plasma proteins to a drug carrier alters the
                      circulation of nanoparticles (NPs) in the bloodstream, and,
                      as a consequence, the anticancer efficiency of the entire
                      nanoparticle drug delivery system. We investigate the
                      possible interaction and the interaction mechanism of a
                      polymeric drug delivery system based on
                      N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers (pHPMA)
                      with the most abundant proteins in human blood
                      plasma—namely, human serum albumin (HSA), immunoglobulin G
                      (IgG), fibrinogen (Fbg), and apolipoprotein (Apo) E4 and
                      A1—using a combination of small-angle X-ray scattering
                      (SAXS), analytical ultracentrifugation (AUC), and nuclear
                      magnetic resonance (NMR). Through rigorous investigation, we
                      present evidence of weak interactions between proteins and
                      polymeric nanomedicine. Such interactions do not result in
                      the formation of the protein corona and do not affect the
                      efficiency of the drug delivery.},
      cin          = {EMBL-User / EMBL},
      ddc          = {610},
      cid          = {I:(DE-H253)EMBL-User-20120814 / I:(DE-H253)EMBL-20120731},
      pnm          = {6G3 - PETRA III (POF3-622)},
      pid          = {G:(DE-HGF)POF3-6G3},
      experiment   = {EXP:(DE-H253)P-P12-20150101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32013056},
      UT           = {WOS:000519268500076},
      doi          = {10.3390/pharmaceutics12020106},
      url          = {https://bib-pubdb1.desy.de/record/449052},
}