2024-04-24 16:34 |
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2024-04-24 16:22 |
[PUBDB-2024-01587]
Journal Article
Mpakali, A. ; Barla, I. ; Lu, L. ; et al
Mechanisms of Allosteric Inhibition of Insulin-Regulated Aminopeptidase
Inhibition of Insulin-Regulated Aminopeptidase is being actively explored for the treatment of several human diseases and several classes of inhibitors have been developed although no clinical applications have been reported yet. Here, we combine enzymological analysis with x-ray crystallography to investigate the mechanism employed by two of the most studied inhibitors of IRAP, an aryl sulfonamide and a 2-amino-4H-benzopyran named HFI-419. [...]
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2024-04-24 16:05 |
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2024-04-24 15:04 |
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2024-04-24 14:23 |
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2024-04-23 16:13 |
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2024-04-23 15:57 |
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2024-04-23 15:48 |
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2024-04-23 15:40 |
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2024-04-23 15:06 |
[PUBDB-2024-01566]
Journal Article
Tamulaitiene, G. ; Sabonis, D. ; Sasnauskas, G. ; et al
Activation of Thoeris antiviral system via SIR2 effector filament assembly
To survive bacteriophage (phage) infections, bacteria developed numerous anti-phage defence systems1,2,3,4,5,6,7. Some of them (for example, type III CRISPR–Cas, CBASS, Pycsar and Thoeris) consist of two modules: a sensor responsible for infection recognition and an effector that stops viral replication by destroying key cellular components8,9,10,11,12. [...]
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