OpenAccess

Human cytomegalovirus (HCMV) is an opportunistic pathogen that infects a majority of the world population. It may cause severe disease in immunocompromised people and lead to pregnancy loss or grave disabilities of the fetus upon congenital infection. [...]

Symbiosis receptor- like kinase SYMRK is required for root nodule symbiosis between legume plants and nitrogen- fixing bacteria. To understand symbiotic signaling from SYMRK, we determined the crystal structure to 1.95 Å and mapped the phosphorylation sites onto the intracellular domain. [...]

We consider black hole formation due to the gravitational collapse produced by large density fluctuations during an epoch of reheating with a stiff equation of state and calculate the induced gravitational wave spectrum. By considering the existing bounds on the total energy density of gravitational waves today, we find constraints on the parameter space of this scenario. [...]

Scenarios with new physics particles feebly interacting with the Standard Model sector provide compelling candidates for dark matter searches. Geared with a set of new experiments for the detection of neutrinos and long-lived particles the Large Hadron Collider (LHC) has joined the hunt for these elusive states. [...]

We examine the implications of the weak gravity conjecture for the mechanisms for discharging cosmological constant via membrane nucleations. Once screening fluxes and membranes which source them enter, and weak gravity bounds are enforced, a generic de Sitter space must be unstable. [...]

Das Hands-on Lab diente neben der Vorstellung des Projekts auch dem gemeinsamen Informations- und Ideenaustausch mit der Community. In fünf Kleingruppen bearbeiteten die Anwesenden folgende Fragestellungen und Themen [...]

Präsentation für den Online-Workshop 'Erste Schritte zum Informationsbudget: Publikationskosten erfassen und sichtbar machen' am 07.02.2024, veranstaltet vom BMBF-Projekt open-access.network

Homology Directed Repair (HDR) enables precise genome editing, but the implementation of HDR-based therapies is hindered by limited efficiency in comparison to methods that exploit alternative DNA repair routes, such as Non-Homologous End Joining (NHEJ). In this study, we develop a functional, pooled screening platform to identify protein-based reagents that improve HDR in human hematopoietic stem and progenitor cells (HSPCs). [...]