Publications database

Heat shock protein 70 (Hsp70) isoforms are key players in the regulation of protein homeostasis and cell death pathways and are therefore attractive targets in cancer research. Developing nucleotide-competitive inhibitors or allosteric modulators, however, has turned out to be very challenging for this protein family, and no Hsp70-directed therapeutics have so far become available. [...]

Acetyl esterases belonging to the carbohydrate esterase family 16 (CE16) is a growing group of enzymes, with exceptional diversity regarding substrate specificity and regioselectivity. However, further insight into the CE16 specificity is required for their efficient biotechnological exploitation. [...]

Human cytomegalovirus (HCMV) is an opportunistic pathogen that infects a majority of the world population. It may cause severe disease in immunocompromised people and lead to pregnancy loss or grave disabilities of the fetus upon congenital infection. [...]

Various subspecies of the unicellular parasite Trypanosoma brucei cause sleeping sickness, a neglected tropical disease affecting millions of individuals and domestic animals. Immune evasion mechanisms play a pivotal role in parasite survival within the host and enable the parasite to establish a chronic infection. [...]

To survive bacteriophage (phage) infections, bacteria developed numerous anti-phage defence systems1,2,3,4,5,6,7. Some of them (for example, type III CRISPR–Cas, CBASS, Pycsar and Thoeris) consist of two modules: a sensor responsible for infection recognition and an effector that stops viral replication by destroying key cellular components8,9,10,11,12. [...]

As an extension of the standard model, Vector Like Quarks provide a possible solution to various unsolved issues, such as the hierarchy problem. This analysis focuses on the single production of the vector-like top quark T′, in the decay channel T′→ tH (H→ WW), in the final state with two opposite sign leptons. [...]

Symbiosis receptor- like kinase SYMRK is required for root nodule symbiosis between legume plants and nitrogen- fixing bacteria. To understand symbiotic signaling from SYMRK, we determined the crystal structure to 1.95 Å and mapped the phosphorylation sites onto the intracellular domain. [...]

Deep Inelastic Scattering (DIS) events at HERA are the most precise DIS measurement to date, which constitutes an important tool to study transverse momentum dependent (TMD) parton distribution functions. In this study, we introduce standard DIS Monte Carlo events recreating HERA conditions, and apply their cross section as a constraint for both photon and heavy boson TMDs in the Parton Branching Method..

We consider black hole formation due to the gravitational collapse produced by large density fluctuations during an epoch of reheating with a stiff equation of state and calculate the induced gravitational wave spectrum. By considering the existing bounds on the total energy density of gravitational waves today, we find constraints on the parameter space of this scenario. [...]

The Standard Model (SM) Higgs boson is predicted to be CP-even. Measurements from Run 2 data at the LHC have excluded a purely CP-odd state at 3 standard deviations. [...]