MPG(-2012)

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2013-04-09
12:53
OpenAccess [PHPPUBDB-26150] Journal Article
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Inhibition of tau filament formation by conformational modulation
ddc:540
Antiaggregation drugs play an important role in therapeutic approaches for Alzheimer's disease. Although a large number of small molecules that inhibit the aggregation of the tau protein have been identified, little is known about their mode of action. [...]
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2013-01-18
20:57
[PHPPUBDB-23570] Journal Article
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Mechanistic Basis of Phenothiazine-driven Inhibition of Tau Aggregation
Angewandte Chemie International Edition 52, 3511-3515 (2013) [10.1002/anie.201208290]  GO

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2013-01-18
20:56
pmc [PHPPUBDB-23647] Journal Article
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Interaction of Tau Protein with Model Lipid Membranes Induces Tau Structural Compaction and Membrane Disruption
ddc:570
The misfolding and aggregation of the intrinsically disordered, microtubule-associated tau protein into neurofibrillary tangles is implicated in the pathogenesis of Alzheimer's disease. However, the mechanisms of tau aggregation and toxicity remain unknown. [...]

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2012-09-19
19:14
[PHPPUBDB-19435] Journal Article
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Structural memory of natively unfolded tau protein detected by small-angle x-ray scattering.
Proteins 79, 2122-2131 (2011) [10.1002/prot.23033]  GO
ddc:540
Small-angle X-ray scattering (SAXS) is a universal low-resolution method to study size and shape of globular proteins in solution but recent developments facilitate the quantitative characterization of the structure and structural transitions of metastable systems like partially or completely unfolded proteins. We present here a study of temperature induced transitions in tau, a natively unfolded protein involved in Alzheimer's disease. [...]

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2012-09-19
19:13
OpenAccess [PHPPUBDB-18289] Journal Article
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Crystallographic snapshots of the complete reaction cycle of nicotine degradation by an amine oxidase of the monoamine oxidase (MAO) family
ddc:000
FAD-linked oxidases constitute a class of enzymes which catalyze dehydrogenation as a fundamental biochemical reaction, followed by reoxidation of reduced flavin. Here, we present high-resolution crystal structures showing the flavoenzyme 6-hydroxy-l-nicotine oxidase in action. [...]
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2012-09-19
19:10
[PHPPUBDB-12176] Journal Article
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Structural and kinetic studies on native intermediates and an intermediate analogue in benzoylformate decarboxylase reveal a least motion mechanism with an unprecedented short-lived predecarboxylation intermediate
Biochemistry 48, 3258-3268 (2009) [10.1021/bi801957d]  GO
ddc:570
The thiamin diphosphate- (ThDP-) dependent enzyme benzoylformate decarboxylase (BFDC) catalyzes the nonoxidative decarboxylation of benzoylformic acid to benzaldehyde and carbon dioxide. To date, no structural information for a cofactor-bound reaction intermediate in BFDC is available. [...]

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2012-09-19
19:09
[PHPPUBDB-12392] Conference Presentation

Momentum imaging of stored molecular ions in ELISA
3rd International Workshop on Electrostatic Storage Devices, Meeting locationAarhus, Denmark, 21 Jun 2009 - 25 Jun 20092009-06-212009-06-25

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2012-09-19
19:07
[PHPPUBDB-12394] Talk (non-conference)

Cooled molecular ions under fire
ISA user meeting 2010, Meeting locationAarhus, Denmark, 28 Jan 2010 - 29 Jan 20102010-01-282010-01-29

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2012-09-19
19:02
[PHPPUBDB-14223] Journal Article
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Temporal coherence effects in multiple ionization of N$_2$ via XUV pump-probe autocorrelation
ddc:530
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2012-09-19
18:59
[PHPPUBDB-14789] Journal Article
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Structure and function of polarity-inducing kinase family MARK/Par-1 within the branch of AMPK/Snf1-related kinases
ddc:570
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