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2019-02-13
16:09
OpenAccess [PUBDB-2019-01079] Journal Article
et al
Curcumin- and Fish Oil-Loaded Spongosome and Cubosome Nanoparticles with Neuroprotective Potential against $H_{2}O_{2}$ -Induced Oxidative Stress in Differentiated Human SH-SY5Y Cells
ACS omega 4(2), 3061 - 3073 () [10.1021/acsomega.8b03101]  GO
Many phytochemical antioxidant compounds, including curcumin (CU), are water-insoluble and thus require delivery carriers in order to increase their bioavailability for in vivo applications. Oxidative stress-related apoptosis is a common cause for the neuronal loss in the progression of neurodegenerative diseases [...]
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ddc:660
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2019-02-11
17:02
Embargoed OpenAccess [PUBDB-2019-01033] Journal Article
et al
A vesicle-to-sponge transition via the proliferation of membrane-linking pores in $ω-3$ polyunsaturated fatty acid-containing lipid assemblies
We investigate the nanostructure evolution and the membrane reorganization of diluted lipid dispersions of self-assembled monoolein (MO)/eicosapentaenoic acid (EPA, 20:5) mixtures by synchrotron small-angle X-ray scattering (SAXS) and cryogenic transmission electron microscopy (cryo-TEM) microscopy. The nonlamellar lipid phase containing a ω-3 polyunsaturated fatty acid was fragmented into stable nanoscale objects with the help of PEGylated lipids. [...]
Published on 2019-01-25. Available in OpenAccess from 2020-01-25.: Download fulltextPDF Download fulltextPDF (PDFA); Restricted: Download fulltextPDF Download fulltextPDF (PDFA);
ddc:540
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2019-01-10
17:15
[PUBDB-2019-00348] Journal Article
et al
Amyloid BETA Peptide Aggregation Process in the Presence of Sugar-Based Surfactants- Conformational and Structural Studies
Biophysical Society 62nd Annual Meeting, San FranciscoSan Francisco, USA, 17 Feb 2018 - 21 Feb 20182018-02-172018-02-21 Biophysical journal 114(3), 221a () [10.1016/j.bpj.2017.11.1233]  GO
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ddc:570
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2019-01-09
16:40
OpenAccess [PUBDB-2019-00241] Journal Article
et al
Extreme amyloid polymorphism in Staphylococcus aureus virulent PSMα peptides
Members of the Staphylococcus aureus phenol-soluble modulin (PSM) peptide family are secreted as functional amyloids that serve diverse roles in pathogenicity and may be present as full-length peptides or as naturally occurring truncations. We recently showed that the activity of PSM$α$3, the most toxic member, stems from the formation of cross-$α$ fibrils, which are at variance with the cross-β fibrils linked with eukaryotic amyloid pathologies [...]
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ddc:500
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2019-01-09
16:15
OpenAccess [PUBDB-2019-00235] Journal Article
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Design and in vitro realization of carbon-conserving photorespiration
Photorespiration recycles ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) oxygenation product, 2-phosphoglycolate, back into the Calvin Cycle. Natural photorespiration, however, limits agricultural productivity by dissipating energy and releasing CO$_2$ [...]
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ddc:500
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2019-01-09
14:50
OpenAccess [PUBDB-2019-00221] Journal Article
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Transposase-DNA Complex Structures Reveal Mechanisms for Conjugative Transposition of Antibiotic Resistance
Cell 173(1), 208 - 220 () [10.1016/j.cell.2018.02.032]  GO
Conjugative transposition drives the emergence of multidrug resistance in diverse bacterial pathogens, yet the mechanisms are poorly characterized. The Tn1549 conjugative transposon propagates resistance to the antibiotic vancomycin used for severe drug-resistant infections [...]
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ddc:610
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2019-01-09
14:48
OpenAccess [PUBDB-2019-00220] Journal Article
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A family of unconventional deubiquitinases with modular chain specificity determinants
Deubiquitinating enzymes (DUBs) regulate ubiquitin signaling by trimming ubiquitin chains or removing ubiquitin from modified substrates. Similar activities exist for ubiquitin-related modifiers, although the enzymes involved are usually not related [...]
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ddc:500
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2019-01-09
14:41
OpenAccess [PUBDB-2019-00218] Journal Article
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Structural insights into the stimulation of S. pombe Dnmt2 catalytic efficiency by the tRNA nucleoside queuosine
Dnmt2 methylates cytosine at position 38 of tRNA$^{Asp}$ in a variety of eukaryotic organisms. A correlation between the presence of the hypermodified nucleoside queuosine (Q) at position 34 of tRNAAsp and the Dnmt2 dependent C38 methylation was recently found in vivo for S [...]
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ddc:600
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2019-01-09
14:06
[PUBDB-2019-00204] Journal Article
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Crystal structure of thebaine 6-O-demethylase from the morphine biosynthesis pathway
Thebaine 6-O-demethylase (T6ODM) from Papaver somniferum (opium poppy), which belongs to the non-heme 2-oxoglutarate/Fe(II)-dependent dioxygenases (ODD) family, is a key enzyme in the morphine biosynthesis pathway. Initially, T6ODM was characterized as an enzyme catalyzing O-demethylation of thebaine to neopinone and oripavine to morphinone. [...]
ddc:540
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2019-01-09
14:05
Embargoed OpenAccess [PUBDB-2019-00203] Journal Article

The role of small-angle scattering in structure-based screening applications
Biophysical reviews 10(5), 1295 - 1310 () [10.1007/s12551-018-0464-x]  GO
In many biomolecular interactions, changes in the assembly states and structural conformations of participants can act as a complementary reporter of binding to functional and thermodynamic assays. This structural information is captured by a number of structural biology and biophysical techniques that are viable either as primary screens in small-scale applications or as secondary screens to complement higher throughput methods. [...]
Published on 2018-10-10. Available in OpenAccess from 2019-10-10.: Download fulltextPDF Download fulltextPDF (PDFA); Restricted: Download fulltextPDF Download fulltextPDF (PDFA);
ddc:570
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