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2018-01-17
09:08
OpenAccess [PUBDB-2018-00669] Journal Article
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Biophysical insights from a single chain camelid antibody directed against the Disrupted-in-Schizophrenia 1 protein
PLoS one 13(1), e0191162 - (2018) [10.1371/journal.pone.0191162]  GO
ddc:500
Accumulating evidence suggests an important role for the Disrupted-in-Schizophrenia 1 (DISC1) protein in neurodevelopment and chronic mental illness. In particular, the C-terminal 300 amino acids of DISC1 have been found to mediate important protein-protein interactions and to harbor functionally important phosphorylation sites and disease-associated polymorphisms. [...]
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2018-01-12
10:46
OpenAccess [PUBDB-2018-00598] Journal Article
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Influenza virus Matrix Protein M1 preserves its conformation with pH, changing multimerization state at the priming stage due to electrostatics
ddc:000
Influenza A virus matrix protein M1 plays an essential role in the virus lifecycle, but its functional and structural properties are not entirely defined. Here we employed small-angle X-ray scattering, atomic force microscopy and zeta-potential measurements to characterize the overall structure and association behavior of the full-length M1 at different pH conditions [...]
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2018-01-12
10:45
[PUBDB-2018-00597] Journal Article
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Small-angle X-Ray analysis of macromolecular structure: the structure of protein NS2 (NEP) in solution
ddc:540
A complex structural analysis of nuclear export protein NS2 (NEP) of influenza virus A has been performed using bioinformatics predictive methods and small-angle X-ray scattering data. The behavior of NEP molecules in a solution (their aggregation, oligomerization, and dissociation, depending on the buffer composition) has been investigated [...]

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2018-01-10
10:43
[PUBDB-2018-00315] Journal Article
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Utilising Staphylococcus aureus immune evasion protein Sbi as a novel vaccine conjugate
ddc:570
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2018-01-08
13:53
[PUBDB-2018-00239] Journal Article
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Studies on the adsorption and desorption of mitoxantrone to lauric acid/albumin coated iron oxide nanoparticles
ddc:540
A rational use of superparamagnetic iron oxide nanoparticles (SPIONs) in drug delivery, diagnostics, and other biomedical applications requires deep understanding of the molecular drug adsorption/desorption mechanisms for proper design of new pharmaceutical formulations. The adsorption and desorption of the cytostatic Mitoxantrone (MTO) to lauric acid-albumin hybrid coated particles SPIONs (SEON$^{LA−HSA}$) was studied by Fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), surface titration, release experiments and small-angle neutron and X-ray scattering. [...]
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2018-01-05
10:46
OpenAccess [PUBDB-2018-00178] Dissertation / PhD Thesis

Structural study of the ASK1:thioredoxin complex
98 pp. (2017) [10.3204/PUBDB-2018-00178] = Dissertation, Charles University in Prague, 2017  GO
The mitogen-activated protein kinase (MAPK) cascade is an essential member of the cell defense system against stressors. The capability and efficiency of the cell reactions to different stress signals depend on signal transduction pathway, where signals from MAPK kinase kinase (MAP3K) are transferred through phosphorylation to downstream MAPK kinase (MAP2K) and finally to MAPK [...]
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2018-01-05
10:39
OpenAccess [PUBDB-2018-00177] Dissertation / PhD Thesis
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Struktur-Funktions-Analyse ausgewählter Proteine des Typ-III-Sekretionssystems aus Yersinia enterocolitica: YopB, YopD, YopQ, SycD
163 pp. (2017) [10.3204/PUBDB-2018-00177] = Dissertation, University of Hamburg, 2017  GO
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2018-01-05
10:33
OpenAccess [PUBDB-2018-00176] Dissertation / PhD Thesis
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Structural Characterization of Small basic protein (Sbp) and Accumulation associated protein (Aap) – two Proteins involved in Biofilm Formation in Staphylococcus epidermidis
119 pp. (2017) [10.3204/PUBDB-2018-00176] = Dissertation, University of Hamburg, 2017  GO
Staphylococcus epidermidis is a nosocomial pathogen, which infects biotic and abiotic surfaces by forming adherent biofilms. Biofilm is a multilayered microbial community formed by the production of an extracellular matrix. [...]
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2018-01-03
14:41
[PUBDB-2018-00076] Conference Presentation
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Assessment of bone mechanical properties and multi-scale structure in the sword of the sword fish
7th International Conference on Mechanics of Biomaterials and Tissues, ICMOBT 2017, Meeting locationWaikoloa, United States of America, 10 Dec 2017 - 14 Dec 20172017-12-102017-12-14
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2017-12-28
13:58
[PUBDB-2017-14141] Journal Article
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Intrinsic thermodynamics of high affinity inhibitor binding to recombinant human carbonic anhydrase IV
ddc:570
Membrane-associated carbonic anhydrase (CA) isoform IV participates in carbon metabolism and pH homeostasis and is implicated in the development of eye diseases such as retinitis pigmentosa and glaucoma. A series of substituted benzenesulfonamides were designed and their binding affinity to CA IV was determined by fluorescent thermal shift assay and isothermal titration calorimetry (ITC). [...]
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