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2019-04-29
15:30
Embargoed OpenAccess [PUBDB-2019-02120] Journal Article
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On a specific state of C$_{60}$ fullerene in N-methyl-2-pyrrolidone solution: Mass spectrometric study
A solution of fullerene C$_{60}$ in N-methylpyrrolidone (NMP) presents a suitable system for obtaining fullerene's clusters with the tunable size. However, the mechanism of fullerenes interaction with polar NMP molecules is still elusive. [...]
Published on 2019-03-18. Available in OpenAccess from 2020-03-18.: Download fulltextPDF Download fulltextPDF (PDFA); Restricted: Download fulltextPDF Download fulltextPDF (PDFA);
ddc:660
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2019-04-08
16:10
[PUBDB-2019-01907] Journal Article
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Structural Variability of EspG Chaperones from Mycobacterial ESX-1, ESX-3, and ESX-5 Type VII Secretion Systems
Type VII secretion systems (ESX) are responsible for transport of multiple proteins in mycobacteria. How different ESX systems achieve specific secretion of cognate substrates remains elusive. [...]
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ddc:610
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2019-04-08
16:03
OpenAccess [PUBDB-2019-01906] Journal Article
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Mechanism of silica–lysozyme composite formation unravelled by in situ fast SAXS
A quantitative understanding of aggregation mechanisms leading to the formation of composites of inorganic nanoparticles (NPs) and proteins in aqueous media is of paramount interest for colloid chemistry. In particular, the interactions between silica (SiO2) NPs and lysozyme (LZM) have attracted attention, because LZM is well-known to adsorb strongly to silica NPs, while at the same time preserving its enzymatic activity [...]
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ddc:620
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2019-04-08
15:53
OpenAccess [PUBDB-2019-01905] Journal Article
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Investigation of charge ratio variation in mRNA – DEAE-dextran polyplex delivery systems
mRNA pharmaceuticals represent a new class of therapeutics, with applications, in cancer vaccination, tumour therapy and protein substitution. Formulations are required to deliver messenger RNA (mRNA) to the target sites where induction of genetic transfection following receptor mediated cell uptake & translation is required.In the current study, the cationic polysaccharide diethylaminoethylen (DEAE) – Dextran was selected as a model system carrier for the investigation of polyplex nanoparticle formation together with mRNA as a function of the molar ratio of the components [...]
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ddc:570
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2019-04-08
10:07
[PUBDB-2019-01893] Journal Article
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Ferrocene-Biotin Conjugates: Synthesis, Structure, Cytotoxic Activity and Interaction with Avidin
ChemPlusChem 81(11), 1191 - 1201 () [10.1002/cplu.201600320]  GO
Friedel–Crafts acylation of ferrocene with d‐biotin, d‐homobiotin and d‐desthiobiotin gave ferrocenyl ketones. These compounds were diastereoselectively reduced to the corresponding alcohols using (R)‐ and (S)‐Me‐CBS‐oxazaborolidine–borane complexes as reducing agents. [...]
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ddc:540
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2019-04-08
09:48
[PUBDB-2019-01889] Journal Article
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Functional and structural insight into properdin control of complement alternative pathway amplification
The EMBO journal 36(8), 1084 - 1099 () [10.15252/embj.201696173]  GO
Properdin (FP) is an essential positive regulator of the complement alternative pathway (AP) providing stabilization of the C3 and C5 convertases, but its oligomeric nature challenges structural analysis. We describe here a novel FP deficiency (E244K) caused by a single point mutation which results in a very low level of AP activity. [...]
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ddc:570
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2019-04-04
13:01
[PUBDB-2019-01853] Journal Article

Crystal structure of a marine glycoside hydrolase family 99-related protein lacking catalytic machinery
Protein science 26(12), 2445 - 2450 () [10.1002/pro.3291]  GO
Algal polysaccharides of diverse structures are one of the most abundant carbon resources for heterotrophic, marine bacteria with coevolved digestive enzymes. A putative sulfo‐mannan polysaccharide utilization locus, which is conserved in marine flavobacteria, contains an unusual GH99‐like protein that lacks the conserved catalytic residues of glycoside hydrolase family 99. [...]
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ddc:610
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2019-04-03
08:41
OpenAccess [PUBDB-2019-01835] Journal Article
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Oligomeric interfaces as a tool in drug discovery: Specific interference with activity of malate dehydrogenase of Plasmodium falciparum in vitro
PLOS ONE 13(4), e0195011 - () [10.1371/journal.pone.0195011]  GO
Malaria remains a major threat to human health, as strains resistant to current therapeutics are discovered. Efforts in finding new drug targets are hampered by the lack of sufficiently specific tools to provide target validation prior to initiating expensive drug discovery projects [...]
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ddc:610
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2019-04-03
08:38
[PUBDB-2019-01834] Journal Article
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Isolation, crystallization and crystal structure determination of bovine kidney Na(+),K(+)-ATPase
Na$^+$,K$^+$-ATPase is responsible for the transport of Na$^+$ and K$^+$ across the plasma membrane in animal cells, thereby sustaining vital electrochemical gradients that energize channels and secondary transporters. The crystal structure of Na$^+$,K$^+$-ATPase has previously been elucidated using the enzyme from native sources such as porcine kidney and shark rectal gland. [...]
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ddc:530
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2019-04-03
08:36
Embargoed OpenAccess [PUBDB-2019-01833] Journal Article
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Structural basis for (p)ppGpp synthesis by the Staphylococcus aureus small alarmone synthetase RelP
The stringent response is a global reprogramming of bacterial physiology that renders cells more tolerant to antibiotics and induces virulence gene expression in pathogens in response to stress. This process is driven by accumulation of the intracellular alarmone guanosine-5′-di(tri)phosphate-3′-diphosphate ((p)ppGpp), which is produced by enzymes of the RelA SpoT homologue (RSH) family. [...]
Published on 2018-01-11. Available in OpenAccess from 2019-01-11.: Download fulltextPDF Download fulltextPDF (PDFA);
ddc:540
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