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2018-12-06
14:15
OpenAccess [PUBDB-2018-05255] Journal Article
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Epsin and Sla2 form assemblies through phospholipid interfaces
In clathrin-mediated endocytosis, adapter proteins assemble together with clathrin through interactions with specific lipids on the plasma membrane. However, the precise mechanism of adapter protein assembly at the cell membrane is still unknown [...]
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ddc:500
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2018-12-06
14:07
OpenAccess [PUBDB-2018-05247] Journal Article
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Structural Basis for Draxin-Modulated Axon Guidance and Fasciculation by Netrin-1 through DCC
Neuron 97(6), 1261 - 1267 () [10.1016/j.neuron.2018.02.010]  GO
Axon guidance involves the spatiotemporal interplay between guidance cues and membrane-bound cell-surface receptors, present on the growth cone of the axon. Netrin-1 is a prototypical guidance cue that binds to deleted in colorectal cancer (DCC), and it has been proposed that the guidance cue Draxin modulates this interaction [...]
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ddc:610
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2018-12-06
14:05
[PUBDB-2018-05246] Journal Article
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Multi-channel in situ dynamic light scattering instrumentation enhancing biological small-angle X-ray scattering experiments at the PETRA III beamline P12
Small-angle X-ray scattering (SAXS) analysis of biomolecules is increasingly common with a constantly high demand for comprehensive and efficient sample quality control prior to SAXS experiments. As monodisperse sample suspensions are desirable for SAXS experiments, latest dynamic light scattering (DLS) techniques are most suited to obtain non-invasive and rapid information about the particle size distribution of molecules in solution. [...]
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ddc:550
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2018-08-20
15:20
[PUBDB-2018-03073] Journal Article
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High concentration aqueous magnetic fluids: structure, colloidal stability, magnetic and flow properties
Soft matter 14(32), 6648 - 6666 () [10.1039/C7SM02417G]  GO
This paper is an in-depth analysis devoted to two basic types of water based magnetic fluids (MFs), containing magnetite nanoparticles with electrostatic and with electro-steric stabilization, both obtained by chemical coprecipitation synthesis under atmospheric conditions. The two sets of magnetic fluid samples, one with citric acid (MF/CA) and the other with oleic acid (MF/OA) coated magnetic nanoparticles, respectively, achieved saturation magnetization values of 78.20 kA m$^{−1}$ for the electrostatically and 48.73 kA m$^{−1}$ for the electro-sterically stabilized aqueous ferrofluids which are among the highest reported to date. [...]
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ddc:530
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2018-01-17
09:08
OpenAccess [PUBDB-2018-00669] Journal Article
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Biophysical insights from a single chain camelid antibody directed against the Disrupted-in-Schizophrenia 1 protein
PLoS one 13(1), e0191162 - () [10.1371/journal.pone.0191162]  GO
Accumulating evidence suggests an important role for the Disrupted-in-Schizophrenia 1 (DISC1) protein in neurodevelopment and chronic mental illness. In particular, the C-terminal 300 amino acids of DISC1 have been found to mediate important protein-protein interactions and to harbor functionally important phosphorylation sites and disease-associated polymorphisms. [...]
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ddc:500
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2018-01-12
10:46
OpenAccess [PUBDB-2018-00598] Journal Article
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Influenza virus Matrix Protein M1 preserves its conformation with pH, changing multimerization state at the priming stage due to electrostatics
Influenza A virus matrix protein M1 plays an essential role in the virus lifecycle, but its functional and structural properties are not entirely defined. Here we employed small-angle X-ray scattering, atomic force microscopy and zeta-potential measurements to characterize the overall structure and association behavior of the full-length M1 at different pH conditions [...]
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ddc:000
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2018-01-12
10:45
[PUBDB-2018-00597] Journal Article
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Small-angle X-Ray analysis of macromolecular structure: the structure of protein NS2 (NEP) in solution
A complex structural analysis of nuclear export protein NS2 (NEP) of influenza virus A has been performed using bioinformatics predictive methods and small-angle X-ray scattering data. The behavior of NEP molecules in a solution (their aggregation, oligomerization, and dissociation, depending on the buffer composition) has been investigated. [...]
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ddc:540
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2018-01-10
10:43
[PUBDB-2018-00315] Journal Article
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Utilising Staphylococcus aureus immune evasion protein Sbi as a novel vaccine conjugate
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ddc:570
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2018-01-08
13:53
[PUBDB-2018-00239] Journal Article
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Studies on the adsorption and desorption of mitoxantrone to lauric acid/albumin coated iron oxide nanoparticles
A rational use of superparamagnetic iron oxide nanoparticles (SPIONs) in drug delivery, diagnostics, and other biomedical applications requires deep understanding of the molecular drug adsorption/desorption mechanisms for proper design of new pharmaceutical formulations. The adsorption and desorption of the cytostatic Mitoxantrone (MTO) to lauric acid-albumin hybrid coated particles SPIONs (SEON$^{LA−HSA}$) was studied by Fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), surface titration, release experiments and small-angle neutron and X-ray scattering. [...]
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2018-01-05
10:46
OpenAccess [PUBDB-2018-00178] Dissertation / PhD Thesis

Structural study of the ASK1:thioredoxin complex
98 pp. () [10.3204/PUBDB-2018-00178] = Dissertation, Charles University in Prague, 2017  GO
The mitogen-activated protein kinase (MAPK) cascade is an essential member of the cell defense system against stressors. The capability and efficiency of the cell reactions to different stress signals depend on signal transduction pathway, where signals from MAPK kinase kinase (MAP3K) are transferred through phosphorylation to downstream MAPK kinase (MAP2K) and finally to MAPK [...]
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