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2017-02-01
17:28
[PUBDB-2017-00829] Journal Article
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C$_{60}$ fullerene enhances cisplatin anticancer activity and overcomes tumor cell drug resistance
Nano research 10(2), 652 - 671 (2017) [10.1007/s12274-016-1324-2]  GO
ddc:540
We formulated and analyzed a novel nanoformulation of the anticancer drug cisplatin (Cis) with C$_{60}$ fullerene (C$_{60}$+Cis complex) and showed its higher toxicity toward tumor cell lines in vitro when compared to Cis alone. The highest toxicity of the complex was observed in HL-60/adr and HL-60/vinc chemotherapy-resistant human leukemia cell sublines (resistant to Adriamycin and Vinculin, respectively). [...]
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2017-01-10
15:04
[PUBDB-2017-00456] Journal Article
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Functionality of whey proteins covalently modified by allyl isothiocyanate. Part 1 physicochemical and antibacterial properties of native and modified whey proteins at pH 2 to 7
ddc:630
Whey protein isolate (WPI) (∼75% β-lactoglobulin (β-LG)) is frequently used in foods as a natural emulsifying agent. However, at an acidic pH value, its emulsification capacity is greatly reduced. [...]
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2017-01-10
15:00
OpenAccess [PUBDB-2017-00455] Journal Article
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Lubrication synergy : Mixture of hyaluronan and dipalmitoylphosphatidylcholine (DPPC) vesicles
ddc:540
Phospholipids and hyaluronan have been implied to fulfil important roles in synovial joint lubrication. Since both components are present in synovial fluid, self-assembly structures formed by them should also be present. [...]
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2017-01-09
10:52
[PUBDB-2017-00280] Journal Article
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Stabilization of aqueous dispersions of poly(methacrylic acid)-coated iron oxide nanoparticles by double hydrophilic block polyelectrolyte poly(ethylene oxide)-block-poly(N-methyl-2-vinylpyridinium iodide)
ddc:540
Aqueous dispersions of poly(methacrylic acid)-coated superparamagnetic iron oxide nanoparticles (PMAA@SPIONs) and nanoparticles obtained by adding a layer of double-hydrophilic cationic block polyelectrolyte poly(ethylene oxide)-block-poly(N-methyl-2-vinylpyridinium iodide) (PEO-QP2VP) on PMAA@SPIONs were studied by a combination of static and dynamic light scattering, SAXS, transmission electron microscopy and atomic force microscopy, probing the structure of the SPION aggregates on the lengthscale from 1 to 10$^3$ nm. Both SALS and AFM results indicate that adding a PEO-QP2VP layer to PMAA@SPIONs decreases the size of SPION aggregates formed in the dispersions. [...]

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2017-01-03
16:31
[PUBDB-2017-00038] Journal Article
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Calcium-Driven Folding of RTX Domainbeta-Rolls Ratchets Translocation of RTXProteins through Type I Secretion Ducts
ddc:570
Calcium-binding RTX proteins are equipped with C-terminal secretion signals and translocate from the Ca$^{2+}$-depleted cytosol of Gram-negative bacteria directly into the Ca$^{2+}$-rich external milieu, passing through the “channel-tunnel” ducts of type I secretion systems (T1SSs). Using Bordetella pertussis adenylate cyclase toxin, we solved the structure of an essential C-terminal assembly that caps the RTX domains of RTX family leukotoxins. [...]
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2016-12-19
15:04
OpenAccess [PUBDB-2016-06349] Dissertation / PhD Thesis

Preparation and scoring of protein nano- and microcrystals for synchrotron and free-electron laser X-ray radiation sources
157 pp., (2016) [10.3204/PUBDB-2016-06349]  GO
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2016-12-12
17:31
[PUBDB-2016-06113] Journal Article
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Molecular studies on structural changes and oligomerisation of violaxanthin de-epoxidase associated with the pH-dependent activation
ddc:580
Violaxanthin de-epoxidase (VDE) is a conditionally soluble enzyme located in the thylakoid lumen and catalyses the conversion of violaxanthin to antheraxanthin and zeaxanthin, which are located in the thylakoid membrane. These reactions occur when the plant or algae are exposed to saturating light and the zeaxanthin formed is involved in the process of non-photochemical quenching that protects the photosynthetic machinery during stress. [...]
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2016-12-12
11:06
OpenAccess [PUBDB-2016-06088] Journal Article
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Structural Characterization of the Avidin Interactions with Fluorescent Pyrene-Conjugates: 1-Biotinylpyrene and 1-Desthiobiotinylpyrene
ddc:540
Avidin is a tetrameric protein that belongs to the calycin superfamily. It has been studied mainly because of its extraordinary affinity to biotin, which led to a wide range of applications based on the avidin-biotin system. [...]
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2016-12-12
11:04
OpenAccess [PUBDB-2016-06087] Journal Article
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Disease-Homologous Mutation in the Cation Diffusion Facilitator Protein MamM Causes Single-Domain Structural Loss and Signifies Its Importance
ddc:000
Cation diffusion facilitators (CDF) are highly conserved, metal ion efflux transporters that maintain divalent transition metal cation homeostasis. Most CDF proteins contain two domains, the cation transporting transmembrane domain and the regulatory cytoplasmic C-terminal domain (CTD). [...]
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2016-12-12
11:00
OpenAccess [PUBDB-2016-06085] Journal Article
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Structural and Functional Characterization of a Ruminal β-Glycosidase Defines a Novel Subfamily of Glycoside Hydrolase Family 3 with Permuted Domain Topology
ddc:570
Metagenomics has opened up a vast pool of genes for putative, yet uncharacterized, enzymes. It widens our knowledge on the enzyme diversity world and discloses new families for which a clear classification is still needed, as is exemplified by glycoside hydrolase family-3 (GH3) proteins. [...]
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