EMBL

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2018-01-12
10:45
[PUBDB-2018-00597] Journal Article
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Small-angle X-Ray analysis of macromolecular structure: the structure of protein NS2 (NEP) in solution
ddc:540
A complex structural analysis of nuclear export protein NS2 (NEP) of influenza virus A has been performed using bioinformatics predictive methods and small-angle X-ray scattering data. The behavior of NEP molecules in a solution (their aggregation, oligomerization, and dissociation, depending on the buffer composition) has been investigated [...]

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2018-01-11
12:32
OpenAccess [PUBDB-2018-00470] Journal Article
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Progress in small-angle scattering from biological solutions at high-brilliance synchrotrons
IUCrJ 4(5), 518 - 528 (2017) [10.1107/S2052252517008740]  GO
ddc:530
Small-angle X-ray scattering (SAXS) is an established technique that provides low-resolution structural information on macromolecular solutions. Recent decades have witnessed significant progress in both experimental facilities and in novel data-analysis approaches, making SAXS a mainstream method for structural biology [...]
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2018-01-10
11:08
Embargoed OpenAccess [PUBDB-2018-00321] Journal Article
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Inactivation of urease by catechol: Kinetics and structure
ddc:540
Urease is a Ni(II)-containing enzyme that catalyzes the hydrolysis of urea to yield ammonia and carbamate at a rate 1015 times higher than the uncatalyzed reaction. Urease is a virulence factor of several human pathogens, in addition to decreasing the efficiency of soil organic nitrogen fertilization. [...]
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2018-01-10
10:46
OpenAccess [PUBDB-2018-00316] Journal Article
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Estimation of the protein–ligand interaction energy for model building and validation
ddc:570
Macromolecular X-ray crystallography is one of the main experimental techniques to visualize protein–ligand interactions. The high complexity of the ligand universe, however, has delayed the development of efficient methods for the automated identification, fitting and validation of ligands in their electron-density clusters. [...]
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2018-01-10
10:43
[PUBDB-2018-00315] Journal Article
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Utilising Staphylococcus aureus immune evasion protein Sbi as a novel vaccine conjugate
ddc:570
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2018-01-05
10:26
OpenAccess [PUBDB-2018-00174] Dissertation / PhD Thesis
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Structural characterization of cell surface receptors involved in axon guidance
166 pp. (2017) [10.3204/PUBDB-2018-00174] = Dissertation, University of Heidelberg, 2017  GO
During neuron development, the precise wiring of neuronal network is mainly secured by molecular probes that prevent synapse formation with sister dendrites, generating repulsive signals. At the same time, cell surface receptors dictate the axon orientation and growth, in response to signaling sources (guidance cues) through attractive or repulsive mechanisms [...]
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2017-12-22
15:16
OpenAccess [PUBDB-2017-14093] Journal Article
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Structural Basis of the Interaction between the Putative Adhesion-Involved and Iron-Regulated FrpD and FrpC Proteins of Neisseria meningitidis
ddc:000
The iron-regulated protein FrpD from $Neisseria$ $meningitidis$ is an outer membrane lipoprotein that interacts with very high affinity ($K_d \sim 0.2$ nM) with the N-terminal domain of FrpC, a Type I-secreted protein from the $\underline{R}$epeat in $\underline{T}$o$\underline{X}$in (RTX) protein family. In the presence of Ca$^{2+}$, FrpC undergoes Ca$^{2+}$-dependent protein trans-splicing that includes an autocatalytic cleavage of the Asp$_{414}$-Pro$_{415}$ peptide bond and formation of an Asp$_{414}$-Lys isopeptide bond. [...]
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2017-12-22
15:14
DBCoverage [PUBDB-2017-14091] Journal Article
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Structural reorganization of the chromatin remodeling enzyme Chd1 upon engagement with nucleosomes
eLife 6, e22510 (2017) [10.7554/eLife.22510]  GO
ddc:500
The yeast Chd1 protein acts to position nucleosomes across genomes. Here, we model the structure of the Chd1 protein in solution and when bound to nucleosomes. [...]
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2017-12-22
14:59
OpenAccess [PUBDB-2017-14083] Preprint
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Molecular mechanism of the dual regulation of bacterial iron sulfur cluster biogenesis by CyaY and IscX
 GO
IscX (or YfhJ) is a protein of unknown function which takes part in the iron-sulfur cluster assembly machinery, a highly specialised and essential metabolic pathway. IscX binds to iron with low affinity and interacts with IscS, the desulfurase central to cluster assembly. [...]
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2017-12-22
14:56
DBCoverage [PUBDB-2017-14081] Journal Article
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Highly selective tungstate transporter protein TupA from Desulfovibrio alaskensis G20
ddc:000
Molybdenum and tungsten are taken up by bacteria and archaea as their soluble oxyanions through high affinity transport systems belonging to the ATP-binding cassette (ABC) transporters. The component A (ModA/TupA) of these transporters is the first selection gate from which the cell differentiates between MoO42−, WO42− and other similar oxyanions. [...]
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