EMBL

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2018-12-06
14:38
OpenAccess [PUBDB-2018-05279] Journal Article
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Structure and function of the N-terminal domain of the yeast telomerase reverse transcriptase
The elongation of single-stranded DNA repeats at the 3′-ends of chromosomes by telomerase is a key process in maintaining genome integrity in eukaryotes. Abnormal activation of telomerase leads to uncontrolled cell division, whereas its down-regulation is attributed to ageing and several pathologies related to early cell death [...]
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ddc:540
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2018-12-06
14:34
OpenAccess [PUBDB-2018-05278] Journal Article
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Structural and functional insights into the unique CBS–CP12 fusion protein family in cyanobacteria
Cyanobacteria are important photosynthetic organisms inhabiting a range of dynamic environments. This phylum is distinctive among photosynthetic organisms in containing genes encoding uncharacterized cystathionine β-synthase (CBS)–chloroplast protein (CP12) fusion proteins. [...]
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ddc:500
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2018-12-06
14:22
[PUBDB-2018-05262] Journal Article
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Structural and Functional Characterization of the BcsG Subunit of the Cellulose Synthase in Salmonella typhimurium
Many bacteria secrete cellulose, which forms the structural basis for bacterial multicellular aggregates, termed biofilms. The cellulose synthase complex of Salmonella typhimurium consists of the catalytic subunits BcsA and BcsB and several auxiliary subunits that are encoded by two divergently transcribed operons, bcsRQABZC and bcsEFG [...]
ddc:610
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2018-12-06
14:15
OpenAccess [PUBDB-2018-05255] Journal Article
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Epsin and Sla2 form assemblies through phospholipid interfaces
In clathrin-mediated endocytosis, adapter proteins assemble together with clathrin through interactions with specific lipids on the plasma membrane. However, the precise mechanism of adapter protein assembly at the cell membrane is still unknown [...]
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ddc:500
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2018-12-06
14:07
OpenAccess [PUBDB-2018-05247] Journal Article
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Structural Basis for Draxin-Modulated Axon Guidance and Fasciculation by Netrin-1 through DCC
Neuron 97(6), 1261 - 1267 () [10.1016/j.neuron.2018.02.010]  GO
Axon guidance involves the spatiotemporal interplay between guidance cues and membrane-bound cell-surface receptors, present on the growth cone of the axon. Netrin-1 is a prototypical guidance cue that binds to deleted in colorectal cancer (DCC), and it has been proposed that the guidance cue Draxin modulates this interaction [...]
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ddc:610
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2018-12-06
14:05
[PUBDB-2018-05246] Journal Article
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Multi-channel in situ dynamic light scattering instrumentation enhancing biological small-angle X-ray scattering experiments at the PETRA III beamline P12
Small-angle X-ray scattering (SAXS) analysis of biomolecules is increasingly common with a constantly high demand for comprehensive and efficient sample quality control prior to SAXS experiments. As monodisperse sample suspensions are desirable for SAXS experiments, latest dynamic light scattering (DLS) techniques are most suited to obtain non-invasive and rapid information about the particle size distribution of molecules in solution [...]
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ddc:550
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2018-10-22
14:31
OpenAccess [PUBDB-2018-03874] Journal Article
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Saposin Lipid Nanoparticles: A Highly Versatile and Modular Tool for Membrane Protein Research
Structure 26(2), 345 - 355 () [10.1016/j.str.2018.01.007]  GO
Saposin-derived lipid nanoparticles (SapNPs) are a new alternative tool for membrane protein reconstitution. Here we demonstrate the potential and advantages of SapNPs [...]
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ddc:540
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2018-10-22
14:28
OpenAccess [PUBDB-2018-03873] Journal Article
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Multispecific Substrate Recognition in a Proton-Dependent Oligopeptide Transporter
Structure 26(3), 467 - 476 () [10.1016/j.str.2018.01.005]  GO
roton-dependent oligopeptide transporters (POTs) are important for uptake of dietary di- and tripeptides in many organisms, and in humans are also involved in drug absorption. These transporters accept a wide range of substrates, but the structural basis for how different peptide side chains are accommodated has so far remained obscure [...]
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ddc:540
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2018-10-22
13:46
OpenAccess [PUBDB-2018-03872] Journal Article
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Tripeptide binding in a proton-dependent oligopeptide transporter
FEBS letters 592(19), 3239 - 3247 () [10.1002/1873-3468.13246]  GO
Proton‐dependent oligopeptide transporters (POTs) are important for the uptake of di‐/tripeptides in many organisms and for drug transport in humans. The binding mode of dipeptides has been well described [...]
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ddc:610
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2018-10-22
13:44
[PUBDB-2018-03870] Journal Article
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Probing the Architecture of a Multi-PDZ Domain Protein: Structure of PDZK1 in Solution
Structure 26(11), 1522 - 1533 () [10.1016/j.str.2018.07.016]  GO
The scaffolding protein PDZK1 has been associated with the regulation of membrane transporters. It contains four conserved PDZ domains, which typically recognize a 3–5-residue long motif at the C terminus of the binding partner [...]
ddc:540
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