EMBL

Latest additions:
2017-10-24
16:33
DBCoverage [PUBDB-2017-11540] Journal Article
; ; ; et al
Tuning the Size of Thermoresponsive Poly(N-Isopropyl Acrylamide) Grafted Silica Microgels
Gels 3(3), 34 (2017) [10.3390/gels3030034]  GO
ddc:540
Core-shell microgels were synthesized via a free radical emulsion polymerization of thermoresponsive poly-(N-isopropyl acrylamide), pNipam, on the surface of silica nanoparticles.Pure pNipam microgels have a lower critical solution temperature (LCST) of about 32 C. The LCST varies slightly with the crosslinker density used to stabilize the gel network. [...]
Restricted: Download fulltextPDF Download fulltextPDF (PDFA); External link: Download fulltextFulltext

Detailed record - Similar records
2017-06-29
15:03
[PUBDB-2017-06408] Contribution to a book
; ;
Advances in Small- and Wide-Angle X-ray Scattering SAXS and WAXS of Proteins
Encyclopedia of Analytical Chemistry / Meyers, Robert A. (Editor) ; Chichester, UK : John Wiley & Sons, Ltd, , ; ISBN: 9780471976707 ; doi:10.1002/9780470027318.a9447 Chichester, UK : John Wiley & Sons, Ltd, --- (2017) [10.1002/9780470027318.a9447]  GO
Small-angle scattering of X-rays (SAXS) is an established method for low-resolution structural characterization of native biological macromolecules in solution. Recent progress in instrumentation (most notably, high brilliance synchrotron sources) and novel data analysis methods significantly enhanced the capabilities of the technique for the structure research. [...]

Detailed record - Similar records
2017-06-29
11:28
[PUBDB-2017-06382] Journal Article
; ; ; et al
Structure and activation of C1, the complex initiating the classical pathway of the complement cascade
ddc:000
The complement system is an important antimicrobial and inflammation-generating component of the innate immune system. The classical pathway of complement is activated upon binding of the 774-kDa C1 complex, consisting of the recognition molecule C1q and the tetrameric protease complex C1r2s2, to a variety of activators presenting specific molecular patterns such as IgG- and IgM-containing immune complexes. [...]
Fulltext: Download fulltextPDF Download fulltextPDF (PDFA);

Detailed record - Similar records
2017-06-29
09:19
[PUBDB-2017-06372] Journal Article
;
The severe impact of in vivo-like microfluidic flow and the influence of gemini surfactants on amyloid aggregation of hen egg white lysozyme
RSC Advances 7(18), 10973 - 10984 (2017) [10.1039/C6RA26675D]  GO
ddc:540
The formation of amyloid plaques is being intensively studied, as this process underlies severe human diseases, including Alzheimer's disease, and the exact mechanism of this specific aggregation has not been resolved yet. The investigation of its formation is accompanied by the search for substances inhibiting this aggregation process. [...]
Fulltext: Download fulltextPDF Download fulltextPDF (PDFA);

Detailed record - Similar records
2017-06-23
14:14
[PUBDB-2017-06004] Journal Article

Insights into Rad3 kinase recruitment from the crystal structure of the DNA damage checkpoint protein Rad26
ddc:570
Metabolic products and environmental factors constantly damage DNA. To protect against these insults and maintain genome integrity, cells have evolved mechanisms to repair DNA lesions. [...]

Detailed record - Similar records
2017-06-23
13:45
[PUBDB-2017-06000] Journal Article
; ; ; et al
Assembly of the elongated collagen prolyl 4-hydroxylase α 2 β 2 heterotetramer around a central α 2 dimer
ddc:540
The role of reactive oxygen species (ROS) in osmotic stress, dextran sulfate sodium (DSS) and cyclic stretch-induced tight junction (TJ) disruption was investigated in Caco-2 cell monolayers in vitro and restraint stress-induced barrier dysfunction in mouse colon in vivo. Live cell imaging showed that osmotic stress, cyclic stretch and DSS triggered rapid production of ROS in Caco-2 cell monolayers, which was blocked by depletion of intracellular Ca2+ by 1,2-bis-(o-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid. [...]
Fulltext: Download fulltextPDF Download fulltextPDF (PDFA);

Detailed record - Similar records
2017-06-23
13:12
[PUBDB-2017-05994] Journal Article
; ; ; et al
Calcium modulates calmodulin/?-actinin 1 interaction with and agonist-dependent internalization of the adenosine A2A receptor
ddc:570
Adenosine receptors are G protein-coupled receptors that sense extracellular adenosine to transmit intracellular signals. One of the four adenosine receptor subtypes, the adenosine A2A receptor (A2AR), has an exceptionally long intracellular C terminus (A2AR-ct) that mediates interactions with a large array of proteins, including calmodulin and α-actinin. [...]

Detailed record - Similar records
2017-06-23
12:01
[PUBDB-2017-05974] Journal Article
; ; ; et al
Significance of Individual Residues at the Regulatory Site of Yeast Pyruvate Decarboxylase for Allosteric Substrate Activation
Biochemistry 56(9), 1285 - 1298 (2017) [10.1021/acs.biochem.6b01158]  GO
ddc:570
The catalytic activity of the allosteric enzyme pyruvate decarboxylase from yeast is strictly controlled by its own substrate pyruvate via covalent binding at a separate regulatory site. Kinetic studies, chemical modifications, cross-linking, small-angle X-ray scattering, and crystal structure analyses have led to a detailed understanding of the substrate activation mechanism at an atomic level with C221 as the core moiety of the regulatory site. [...]

Detailed record - Similar records
2017-06-23
11:52
OpenAccess [PUBDB-2017-05971] Journal Article
; ; ; et al
Joint small-angle X-ray and neutron scattering data analysis of asymmetric lipid vesicles
ddc:540
Low- and high-resolution models describing the internal transbilayer structure of asymmetric lipid vesicles have been developed. These models can be used for the joint analysis of small-angle neutron and X-ray scattering data. [...]
OpenAccess: Download fulltextPDF Download fulltextPDF (PDFA);

Detailed record - Similar records
2017-06-23
09:51
[PUBDB-2017-05918] Journal Article
; ;
Dicationic Surfactants with Glycine Counter Ions for Oligonucleotide Transportation
ChemPhysChem 17(15), 2424 - 2433 (2016) [10.1002/cphc.201600175]  GO
ddc:540
Gemini surfactants are good candidates to bind, protect, and deliver nucleic acids. Herein, the concept of amino acids (namely glycine) as counter ions of gemini surfactants for gene therapy application was explored. [...]
Fulltext: Download fulltextPDF Download fulltextPDF (PDFA);

Detailed record - Similar records