EMBL

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2017-06-23
14:14
[PUBDB-2017-06004] Journal Article

Insights into Rad3 kinase recruitment from the crystal structure of the DNA damage checkpoint protein Rad26
ddc:570
Metabolic products and environmental factors constantly damage DNA. To protect against these insults and maintain genome integrity, cells have evolved mechanisms to repair DNA lesions. [...]

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2017-06-23
13:45
[PUBDB-2017-06000] Journal Article
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Assembly of the elongated collagen prolyl 4-hydroxylase α 2 β 2 heterotetramer around a central α 2 dimer
ddc:540
The role of reactive oxygen species (ROS) in osmotic stress, dextran sulfate sodium (DSS) and cyclic stretch-induced tight junction (TJ) disruption was investigated in Caco-2 cell monolayers in vitro and restraint stress-induced barrier dysfunction in mouse colon in vivo. Live cell imaging showed that osmotic stress, cyclic stretch and DSS triggered rapid production of ROS in Caco-2 cell monolayers, which was blocked by depletion of intracellular Ca2+ by 1,2-bis-(o-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid. [...]
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2017-06-23
13:12
[PUBDB-2017-05994] Journal Article
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Calcium modulates calmodulin/?-actinin 1 interaction with and agonist-dependent internalization of the adenosine A2A receptor
ddc:570
Adenosine receptors are G protein-coupled receptors that sense extracellular adenosine to transmit intracellular signals. One of the four adenosine receptor subtypes, the adenosine A2A receptor (A2AR), has an exceptionally long intracellular C terminus (A2AR-ct) that mediates interactions with a large array of proteins, including calmodulin and α-actinin. [...]

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2017-06-23
12:01
[PUBDB-2017-05974] Journal Article
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Significance of Individual Residues at the Regulatory Site of Yeast Pyruvate Decarboxylase for Allosteric Substrate Activation
Biochemistry 56(9), 1285 - 1298 (2017) [10.1021/acs.biochem.6b01158]  GO
ddc:570
The catalytic activity of the allosteric enzyme pyruvate decarboxylase from yeast is strictly controlled by its own substrate pyruvate via covalent binding at a separate regulatory site. Kinetic studies, chemical modifications, cross-linking, small-angle X-ray scattering, and crystal structure analyses have led to a detailed understanding of the substrate activation mechanism at an atomic level with C221 as the core moiety of the regulatory site. [...]

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2017-06-23
11:52
OpenAccess [PUBDB-2017-05971] Journal Article
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Joint small-angle X-ray and neutron scattering data analysis of asymmetric lipid vesicles
ddc:540
Low- and high-resolution models describing the internal transbilayer structure of asymmetric lipid vesicles have been developed. These models can be used for the joint analysis of small-angle neutron and X-ray scattering data. [...]
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2017-06-23
09:51
[PUBDB-2017-05918] Journal Article
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Dicationic Surfactants with Glycine Counter Ions for Oligonucleotide Transportation
ChemPhysChem 17(15), 2424 - 2433 (2016) [10.1002/cphc.201600175]  GO
ddc:540
Gemini surfactants are good candidates to bind, protect, and deliver nucleic acids. Herein, the concept of amino acids (namely glycine) as counter ions of gemini surfactants for gene therapy application was explored. [...]
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2017-06-23
09:21
[PUBDB-2017-05909] Journal Article
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Molecular Precision and Enzymatic Degradation: From Readily to Undegradable Polymeric Micelles by Minor Structural Changes
ddc:540
Studying the enzymatic degradation of synthetic polymers is crucial for the design of suitable materials for biomedical applications ranging from advanced drug delivery systems to tissue engineering. One of the key parameters that governs enzymatic activity is the limited accessibility of the enzyme to its substrates that may be collapsed inside hydrophobic domains. [...]
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2017-06-22
17:11
OpenAccess [PUBDB-2017-05903] Journal Article
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Combination of Whole Genome Sequencing, Linkage, and Functional Studies Implicates a Missense Mutation in Titin as a Cause of Autosomal Dominant Cardiomyopathy With Features of Left Ventricular NoncompactionCLINICAL PERSPECTIVE
ddc:610
Background — High throughput next-generation sequencing techniques have made whole genome sequencing accessible in clinical practice; however, the abundance of variation in the human genomes makes the identification of a disease-causing mutation on a background of benign rare variants challenging. Methods and Results — Here we combine whole genome sequencing with linkage analysis in a 3-generation family affected by cardiomyopathy with features of autosomal dominant left ventricular noncompaction cardiomyopathy. [...]
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2017-06-22
16:59
OpenAccess [PUBDB-2017-05899] Journal Article
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A small and robust active beamstop for scattering experiments on high-brilliance undulator beamlines
ddc:540
A small active in-vacuum beamstop has been developed to monitor the flux of intense third-generation synchrotron X-ray beams protecting the downstream detector from the direct beam. Standard active beamstops, where a built-in diode directly absorbs the beam, have limitations in size and lifetime. [...]
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2017-06-22
16:58
[PUBDB-2017-05898] Journal Article
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A small and robust active beamstop for scattering experiments on high-brilliance undulator beamlines
ddc:540
A small active in-vacuum beamstop has been developed to monitor the flux of intense third-generation synchrotron X-ray beams protecting the downstream detector from the direct beam. Standard active beamstops, where a built-in diode directly absorbs the beam, have limitations in size and lifetime. [...]
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