EMBL

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2019-01-04
10:25
OpenAccess [PUBDB-2019-00037] Journal Article
et al
Robo1 Forms a Compact Dimer-of-Dimers Assembly
Structure 26(2), 320 - 328 () [10.1016/j.str.2017.12.003]  GO
Roundabout (Robo) receptors provide an essential repulsive cue in neuronal development following Slit ligand binding. This important signaling pathway can also be hijacked in numerous cancers, making Slit-Robo an attractive therapeutic target [...]
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ddc:540
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2018-12-19
16:37
OpenAccess [PUBDB-2018-05763] Journal Article
et al
Disease Variants of FGFR3 Reveal Molecular Basis for the Recognition and Additional Roles for Cdc37 in Hsp90 Chaperone System
Structure 26(3), 446 - 458.e8 () [10.1016/j.str.2018.01.016]  GO
Receptor tyrosine kinase FGFR3 is involved in many signaling networks and is frequently mutated in developmental disorders and cancer. The Hsp90/Cdc37 chaperone system is essential for function of normal and neoplastic cells [...]
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ddc:540
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2018-12-19
16:36
[PUBDB-2018-05762] Preprint
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Utilisation of staphylococcal immune evasion protein Sbi as a novel vaccine adjuvant

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2018-12-19
16:24
OpenAccess [PUBDB-2018-05759] Journal Article
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Structural complexity of the co-chaperone SGTA: a conserved C-terminal region is implicated in dimerization and substrate quality control
Protein quality control mechanisms are essential for cell health and involve delivery of proteins to specific cellular compartments for recycling or degradation. In particular, stray hydrophobic proteins are captured in the aqueous cytosol by a co-chaperone, the small glutamine-rich, tetratricopeptide repeat-containing protein alpha (SGTA), which facilitates the correct targeting of tail-anchored membrane proteins, as well as the sorting of membrane and secretory proteins that mislocalize to the cytosol and endoplasmic reticulum-associated degradation [...]
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ddc:610
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2018-12-19
16:21
[PUBDB-2018-05758] Journal Article
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Macromolecular p HPMA-Based Nanoparticles with Cholesterol for Solid Tumor Targeting: Behavior in HSA Protein Environment
Biomacromolecules 19(2), 470 - 480 () [10.1021/acs.biomac.7b01579]  GO
Nanoparticles (NPs) that form by self-assembly of amphiphilic poly(N-(2-hydroxypropyl)-methacrylamide) (pHPMA) copolymers bearing cholesterol side groups are potential drug carriers for solid tumor treatment. Here, we investigate their behavior in solutions of human serum albumin (HSA) in phosphate buffered saline. [...]
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ddc:570
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2018-12-18
17:01
OpenAccess [PUBDB-2018-05714] Journal Article
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Structural model of human dUTPase in complex with a novel proteinaceous inhibitor
Human deoxyuridine 5′-triphosphate nucleotidohydrolase (dUTPase), essential for DNA integrity, acts as a survival factor for tumor cells and is a target for cancer chemotherapy. Here we report that the Staphylococcal repressor protein StlSaPIBov1 (Stl) forms strong complex with human dUTPase [...]
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ddc:600
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2018-12-18
16:16
[PUBDB-2018-05702] Journal Article
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Comprehensive Study of the Self-Assembly of Phospholipid Nanodiscs: What Determines Their Shape and Stoichiometry?
Langmuir 34(42), 12569 - 12582 () [10.1021/acs.langmuir.8b01503]  GO
Phospholipid nanodiscs have quickly become a widely used platform for studies of membrane proteins. However, the molecular self-assembly process that ultimately should place a membrane protein inside a nanodisc is not well understood. [...]
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2018-12-18
16:06
[PUBDB-2018-05699] Journal Article
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Functional interaction of low-homology FRPs from different cyanobacteria with Synechocystis OCP
Photosynthesis requires a balance between efficient light harvesting and protection against photodamage. The cyanobacterial photoprotection system uniquely relies on the functioning of the photoactive orange carotenoid protein (OCP) that under intense illumination provides fluorescence quenching of the light-harvesting antenna complexes, phycobilisomes. [...]
ddc:570
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2018-12-18
14:48
OpenAccess [PUBDB-2018-05683] Journal Article
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A General Small-Angle X-ray Scattering-Based Screening Protocol Validated for Protein–RNA Interactions
We present a screening protocol utilizing small-angle X-ray scattering (SAXS) to obtain structural information on biomolecular interactions independent of prior knowledge, so as to complement affinity-based screening and provide leads for further exploration. This protocol categorizes ligand titrations by computing pairwise agreement between curves, and separately estimates affinities by quantifying complex formation as a departure from the linear sum properties of solution SAXS [...]
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2018-12-18
14:26
OpenAccess [PUBDB-2018-05678] Journal Article
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The Molecular Bases of the Dual Regulation of Bacterial Iron Sulfur Cluster Biogenesis by CyaY and IscX
scX (or YfhJ) is a protein of unknown function which takes part in the iron-sulfur cluster assembly machinery, a highly specialized and essential metabolic pathway. IscX binds to iron with low affinity and interacts with IscS, the desulfurase central to cluster assembly [...]
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ddc:570
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