EMBL

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2019-10-07
11:45
OpenAccess [PUBDB-2019-03606] Journal Article
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The free energy landscape of the oncogene protein E7 of human papillomavirus type 16 reveals a complex interplay between ordered and disordered regions
When present, structural disorder makes it very challenging to characterise the conformational properties of proteins. This is particularly the case of proteins, such as the oncogene protein E7 of human papillomavirus type 16, which contain both ordered and disordered domains, and that can populate monomeric and oligomeric states under physiological conditions. [...]
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ddc:600
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2019-10-07
11:40
OpenAccess [PUBDB-2019-03605] Journal Article
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Octa-repeat domain of the mammalian prion protein mRNA forms stable A-helical hairpin structure rather than G-quadruplexes
Misfolding and aggregation of prion protein (PrP) causes neurodegenerative diseases like Creutzfeldt-Jakob disease (CJD) and scrapie. Besides the consensus that spontaneous conversion of normal cellular PrPC into misfolded and aggregating PrPSc is the central event in prion disease, an alternative hypothesis suggests the generation of pathological PrPSc by rare translational frameshifting events in the octa-repeat domain of the PrP mRNA. [...]
ddc:600
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2019-10-07
11:30
[PUBDB-2019-03603] Journal Article
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Studying Conformational Changes of the Yersinia Type-III-Secretion Effector YopO in Solution by Integrative Structural Biology
Structure 27(9), 1416 - 1426.e3 () [10.1016/j.str.2019.06.007]  GO
The type-III secretion effector YopO helps pathogenic Yersinia to outmaneuver the human immune system. Injected into host cells, it functions as a Ser/Thr kinase after activation by actin binding. [...]
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ddc:540
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2019-10-07
11:13
OpenAccess [PUBDB-2019-03599] Journal Article
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Structure of the lipoprotein lipase–GPIHBP1 complex that mediates plasma triglyceride hydrolysis
The intravascular processing of triglyceride-rich lipoproteins by the lipoprotein lipase (LPL)–GPIHBP1 complex is crucial for clearing triglycerides from the bloodstream and for the delivery of lipid nutrients to vital tissues. A deficiency of either LPL or GPIHBP1 impairs triglyceride processing, resulting in severe hypertriglyceridemia (chylomicronemia). [...]
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ddc:500
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2019-10-02
15:49
[PUBDB-2019-03585] Journal Article
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Solution Structure, Self-Assembly, and Membrane Interactions of the Matrix Protein from Newcastle Disease Virus at Neutral and Acidic pH
Journal of virology 93(6), e01450-18/jvi/93/6/JVI.01450-18.atom () [10.1128/JVI.01450-18]  GO
Newcastle disease virus (NDV) is an enveloped paramyxovirus. The matrix protein of the virus (M-NDV) has an innate propensity to produce virus-like particles budding from the plasma membrane of the expressing cell without recruiting other viral proteins. [...]
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ddc:610
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2019-10-02
15:01
[PUBDB-2019-03581] Journal Article
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Molecular Organization of Soluble Type III Secretion System Sorting Platform Complexes
Many medically relevant Gram‐negative bacteria use the type III secretion system (T3SS) to translocate effector proteins into the host for their invasion and intracellular survival. A multi-protein complex located at the cytosolic interface of the T3SS is proposed to act as a sorting platform by selecting and targeting substrates for secretion through the system. [...]
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ddc:610
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2019-10-02
14:40
[PUBDB-2019-03579] Journal Article
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Solution structure and flexibility of the condensin HEAT-repeat subunit Ycg1
JBC papers in press 294(37), 13822 - 13829 () [10.1074/jbc.RA119.008661]  GO
ddc:610
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2019-10-02
13:34
OpenAccess [PUBDB-2019-03571] Journal Article
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Conformational characterization of full-length X-chromosome-linked inhibitor of apoptosis protein (XIAP) through an integrated approach
IUCrJ 6(5), 948 - 957 () [10.1107/S205225251901073X]  GO
The X-chromosome-linked inhibitor of apoptosis protein (XIAP) is a multidomain protein whose main function is to block apoptosis by caspase inhibition. XIAP is also involved in other signalling pathways, including NF-κB activation and copper homeostasis. [...]
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ddc:530
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2019-10-02
13:32
OpenAccess [PUBDB-2019-03570] Journal Article
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Shedding Light on the Interaction of Human Anti-Apoptotic Bcl-2 Protein with Ligands through Biophysical and in Silico Studies
Bcl-2 protein is involved in cell apoptosis and is considered an interesting target for anti-cancer therapy. The present study aims to understand the stability and conformational changes of Bcl-2 upon interaction with the inhibitor venetoclax, and to explore other drug-target regions [...]
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ddc:540
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2019-10-02
12:04
[PUBDB-2019-03563] Journal Article
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cGAS facilitates sensing of extracellular cyclic dinucleotides to activate innate immunity
EMBO reports 20(4), e46293 () [10.15252/embr.201846293]  GO
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ddc:570
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