EMBL

Latest additions:
2017-04-12
14:47
[PUBDB-2017-01665] Journal Article
; ; ; et al
Structure of the mycobacterial ESX-5 type VII secretion system membrane complex by single-particle analysis
ddc:570
Mycobacteria are characterized by their impermeable outer membrane, which is rich in mycolic acids$^1$. To transport substrates across this complex cell envelope, mycobacteria rely on type VII (also known as ESX) secretion systems$^2$. [...]
Fulltext: Nature Microbiol. 2 (2017) 17047, Suppl. - Download fulltextPDF; Nature Microbiol. 2 (2017) 17047 - Download fulltextPDF;

Detailed record - Similar records
2017-01-10
10:54
OpenAccess [PUBDB-2017-00433] Journal Article
; ; ; et al
Merging of synchrotron serial crystallographic data by a genetic algorithm
ddc:570
Recent advances in macromolecular crystallography have made it practical to rapidly collect hundreds of sub-data sets consisting of small oscillations of incomplete data. This approach, generally referred to as serial crystallography, has many uses, including an increased effective dose per data set, the collection of data from crystals without harvesting (in situ data collection) and studies of dynamic events such as catalytic reactions. [...]
OpenAccess: Download fulltextPDF;

Detailed record - Similar records
2017-01-10
10:52
OpenAccess [PUBDB-2017-00432] Journal Article
; ; ; et al
Anisotropic lanthanide-based nano-clusters for imaging applications
ddc:540
We have developed a new class of lanthanide nano-clusters that self-assemble using flexible Schiff base ligands. Cd–Ln and Ni–Ln clusters, [Ln$_8$Cd$_{24}$(L$^1$)$_{12}$(OAc)$_{39}$Cl$_7$(OH)$_2$] (Ln = Nd, Eu), [Eu8Cd24(L1)12(OAc)44], [Ln$_8$Cd$_{24}$(L$^2$)$_{12}$(OAc)$_{44}$] (Ln = Nd, Yb, Sm) and [Nd$_2$Ni$_4$(L$^3$)$_2$(acac)$_6$(NO$_3$)$_2$(OH)$_2$], were constructed using different types of flexible Schiff base ligands. [...]
OpenAccess: Download fulltextPDF;

Detailed record - Similar records
2017-01-10
10:46
OpenAccess [PUBDB-2017-00431] Journal Article
; ; ; et al
Structural Insights into the Polyphyletic Origins of Glycyl tRNA Synthetases
ddc:570
Glycyl tRNA synthetase (GlyRS) provides a unique case among class II aminoacyl tRNA synthetases (aaRSs), with two clearly widespread types of enzymes: a dimeric ($\alpha_2$) species present in some bacteria, archaea, and eukaryotes, and a heterotetrameric form ($\alpha_{2}\beta_2$) present in most bacteria. Although the differences between both types of GlyRS at the anticodon binding domain level are evident, the extent and implications of the variations in the catalytic domain have not been described and it is unclear whether the mechanism of amino acid recognition is also dissimilar. [...]
OpenAccess: Download fulltextPDF;

Detailed record - Similar records
2017-01-10
10:13
[PUBDB-2017-00422] Journal Article
; ; ; et al
Structural characterization of a Vatairea macrocarpa lectin in complex with a tumor-associated antigen: A new tool for cancer research
ddc:540
Legume lectins are the most thoroughly studied group of lectins and have been widely linked to many pathological processes. Their use as immunohistochemistry markers for cell profiling and cancer diagnosis have made these molecules important tools for immunological studies and have stimulated the prospection and characterization of new lectins. [...]
Restricted: Download fulltextPDF;

Detailed record - Similar records
2017-01-10
10:04
OpenAccess [PUBDB-2017-00416] Journal Article
; ; ; et al
X-Ray Solution Scattering Study of Four Escherichia coli Enzymes Involved in Stationary-Phase Metabolism
PLoS one 11(5), e0156105 - (2016) [10.1371/journal.pone.0156105]  GO
ddc:500
The structural analyses of four metabolic enzymes that maintain and regulate the stationary growth phase of Escherichia coli have been performed primarily drawing on the results obtained from solution small angle X-ray scattering (SAXS) and other structural techniques. The proteins are (i) class I fructose-1,6-bisphosphate aldolase (FbaB); (ii) inorganic pyrophosphatase (PPase); (iii) 5-keto-4-deoxyuronate isomerase (KduI); and (iv) glutamate decarboxylase (GadA). [...]
OpenAccess: Download fulltextPDF;

Detailed record - Similar records
2017-01-10
10:02
[PUBDB-2017-00414] Journal Article
; ; ; et al
Virus Matryoshka: A Bacteriophage Particle-Guided Molecular Assembly Approach to a Monodisperse Model of the Immature Human Immunodeficiency Virus
Small 12(42), 5862 - 5872 (2016) [10.1002/smll.201601712]  GO
ddc:540
Immature human immunodeficiency virus type 1 (HIV-1) is approximately spherical, but is constructed from a hexagonal lattice of the Gag protein. As a hexagonal lattice is necessarily flat, the local symmetry cannot be maintained throughout the structure. [...]
Restricted: Download fulltextPDF;

Detailed record - Similar records
2017-01-10
09:57
OpenAccess [PUBDB-2017-00413] Journal Article
; ; ; et al
Flexibility of KorA, a plasmid-encoded, global transcription regulator, in the presence and the absence of its operator
ddc:540
The IncP (Incompatibility group P) plasmids are important carriers in the spread of antibiotic resistance across Gram-negative bacteria. Gene expression in the IncP-1 plasmids is stringently controlled by a network of four global repressors, KorA, KorB, TrbA and KorC interacting cooperatively. [...]
OpenAccess: Download fulltextPDF;

Detailed record - Similar records
2017-01-10
09:50
[PUBDB-2017-00407] Journal Article
; ; ; et al
Characterization of mAb dimers reveals predominant dimer forms common in therapeutic mAbs
mAbs 8(5), 928 - 940 (2016) [10.1080/19420862.2016.1168960]  GO
ddc:570
The formation of undesired high molecular weight species such as dimers is an important quality attribute for therapeutic monoclonal antibody formulations. Therefore, the thorough understanding of mAb dimerization and the detailed characterization mAb dimers is of great interest for future pharmaceutical development of therapeutic antibodies. [...]

Detailed record - Similar records
2017-01-10
09:45
[PUBDB-2017-00403] Journal Article
; ; ; et al
Structural and functional dissection of Toxoplasma gondii armadillo repeats only protein
Journal of cell science 129(5), 1031 - 1045 (2016) [10.1242/jcs.177386]  GO
ddc:570
Rhoptries are club-shaped, regulated secretory organelles that cluster at the apical pole of apicomplexan parasites. Their discharge is essential for invasion and the establishment of an intracellular lifestyle. [...]
Restricted: Download fulltextPDF;

Detailed record - Similar records