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2017-08-29
11:02
[PUBDB-2017-10033] Journal Article
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Structure of a pathogenic type 3 secretion system in action
ddc:570
Type 3 secretion systems use 3.5-megadalton syringe-like, membrane-embedded 'injectisomes', each containing an ~800-Å-long needle complex to connect intracellular compartments of infectious bacteria and hosts. Here we identify requirements for substrate association with, transport through and exit from the injectisome of Salmonella enterica serovar Typhimurium. [...]
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2017-08-22
16:28
[PUBDB-2017-09664] Journal Article
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Bacterial Type III Secretion Systems: Specialized Nanomachines for Protein Delivery into Target Cells
ddc:570
One of the most exciting developments in the field of bacterial pathogenesis in recent years is the discovery that many pathogens utilize complex nanomachines to deliver bacterially encoded effector proteins into target eukaryotic cells. These effector proteins modulate a variety of cellular functions for the pathogen's benefit. [...]
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2017-08-22
16:26
OpenAccess [PUBDB-2017-09663] Journal Article
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A cooperative mechanism drives budding yeast kinetochore assembly downstream of CENP-A
ddc:570
Kinetochores are megadalton-sized protein complexes that mediate chromosome–microtubule interactions in eukaryotes. How kinetochore assembly is triggered specifically on centromeric chromatin is poorly understood. [...]
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2017-08-22
16:20
[PUBDB-2017-09661] Journal Article
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Atomic-accuracy models from 4.5-Å cryo-electron microscopy data with density-guided iterative local refinement
Nature methods 12(4), 361 - 365 (2015) [10.1038/nmeth.3286]  GO
ddc:570
We describe a general approach for refining protein structure models on the basis of cryo-electron microscopy maps with near-atomic resolution. The method integrates Monte Carlo sampling with local density-guided optimization, Rosetta all-atom refinement and real-space B-factor fitting. [...]
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2017-08-22
16:16
[PUBDB-2017-09660] Journal Article

EM of Pathogen Secretion Systems: Unfolded Protein Transport across Membranes in Action
The FASEB journal 29, 488.2 (2015)  GO
ddc:570
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2017-08-22
16:09
OpenAccess [PUBDB-2017-09658] Journal Article
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Structural and Functional Characterization of the Bacterial Type III Secretion Export Apparatus
ddc:610
Bacterial type III protein secretion systems inject effector proteins into eukaryotic host cells in order to promote survival and colonization of Gram-negative pathogens and symbionts. Secretion across the bacterial cell envelope and injection into host cells is facilitated by a so-called injectisome [...]
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2017-08-21
15:26
OpenAccess [PUBDB-2017-09604] Journal Article
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Control of type III protein secretion using a minimal genetic system
ddc:500
Gram-negative bacteria secrete proteins using a type III secretion system (T3SS), which functions as a needle-like molecular machine. The many proteins involved in T3SS construction are tightly regulated due to its role in pathogenesis and motility [...]
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2017-04-12
14:47
Embargoed OpenAccess [PUBDB-2017-01665] Journal Article
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Structure of the mycobacterial ESX-5 type VII secretion system membrane complex by single-particle analysis
ddc:570
Mycobacteria are characterized by their impermeable outer membrane, which is rich in mycolic acids$^1$. To transport substrates across this complex cell envelope, mycobacteria rely on type VII (also known as ESX) secretion systems$^2$. [...]
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2017-01-10
10:58
OpenAccess [PUBDB-2017-00434] Journal Article
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VirB8-like protein TraH is crucial for DNA transfer in Enterococcus faecalis
ddc:000
Untreatable bacterial infections caused by a perpetual increase of antibiotic resistant strains represent a serious threat to human healthcare in the 21st century. Conjugative DNA transfer is the most important mechanism for antibiotic resistance and virulence gene dissemination among bacteria and is mediated by a protein complex, known as type IV secretion system (T4SS). [...]
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2017-01-10
10:10
[PUBDB-2017-00420] Journal Article
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The BTB domains of the potassium channel tetramerization domain proteins prevalently assume pentameric states
FEBS letters 590(11), 1663 - 1671 (2016) [10.1002/1873-3468.12203]  GO
ddc:570
Potassium channel tetramerization domain-containing (KCTD) proteins are involved in fundamental physio-pathological processes. Here, we report an analysis of the oligomeric state of the Bric-à-brack, Tram-track, Broad complex (BTB) domains of seven distinct KCTDs belonging to five major clades of the family evolution tree. [...]
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