CSSB-EMBL

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2018-10-22
14:31
OpenAccess [PUBDB-2018-03874] Journal Article
; ; ; et al
Saposin Lipid Nanoparticles: A Highly Versatile and Modular Tool for Membrane Protein Research
Structure 26(2), 345 - 355 () [10.1016/j.str.2018.01.007]  GO
Saposin-derived lipid nanoparticles (SapNPs) are a new alternative tool for membrane protein reconstitution. Here we demonstrate the potential and advantages of SapNPs [...]
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ddc:540
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2018-10-22
14:28
OpenAccess [PUBDB-2018-03873] Journal Article
; ; ; et al
Multispecific Substrate Recognition in a Proton-Dependent Oligopeptide Transporter
Structure 26(3), 467 - 476 () [10.1016/j.str.2018.01.005]  GO
roton-dependent oligopeptide transporters (POTs) are important for uptake of dietary di- and tripeptides in many organisms, and in humans are also involved in drug absorption. These transporters accept a wide range of substrates, but the structural basis for how different peptide side chains are accommodated has so far remained obscure [...]
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ddc:540
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2018-10-22
13:46
OpenAccess [PUBDB-2018-03872] Journal Article
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Tripeptide binding in a proton-dependent oligopeptide transporter
FEBS letters 592(19), 3239 - 3247 () [10.1002/1873-3468.13246]  GO
Proton‐dependent oligopeptide transporters (POTs) are important for the uptake of di‐/tripeptides in many organisms and for drug transport in humans. The binding mode of dipeptides has been well described [...]
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ddc:610
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2018-10-22
13:44
[PUBDB-2018-03870] Journal Article
; ; ; et al
Probing the Architecture of a Multi-PDZ Domain Protein: Structure of PDZK1 in Solution
Structure 26(11), 1522 - 1533 () [10.1016/j.str.2018.07.016]  GO
The scaffolding protein PDZK1 has been associated with the regulation of membrane transporters. It contains four conserved PDZ domains, which typically recognize a 3–5-residue long motif at the C terminus of the binding partner [...]
ddc:540
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2017-12-14
15:03
OpenAccess [PUBDB-2017-13499] Journal Article
; ; ; et al
Lipid-like Peptides can Stabilize Integral Membrane Proteins for Biophysical and Structural Studies
ChemBioChem 18(17), 1735 - 1742 () [10.1002/cbic.201700235]  GO
A crucial bottleneck in membrane protein structural biology is the difficulty in identifying a detergent that can maintain the stability and functionality of integral membrane proteins (IMPs). Detergents are poor membrane mimics, and their common use in membrane protein crystallography may be one reason for the challenges in obtaining high-resolution crystal structures of many IMP families. [...]
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ddc:540
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