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2017-12-14
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OpenAccess [PUBDB-2017-13499] Journal Article
; ; ; et al
Lipid-like Peptides can Stabilize Integral Membrane Proteins for Biophysical and Structural Studies
ChemBioChem 18(17), 1735 - 1742 (2017) [10.1002/cbic.201700235]  GO
A crucial bottleneck in membrane protein structural biology is the difficulty in identifying a detergent that can maintain the stability and functionality of integral membrane proteins (IMPs). Detergents are poor membrane mimics, and their common use in membrane protein crystallography may be one reason for the challenges in obtaining high-resolution crystal structures of many IMP families. [...]
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