CFEL-I

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2017-12-07
18:43
OpenAccess [PUBDB-2017-12921] Journal Article
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Incoherent Diffractive Imaging via Intensity Correlations of Hard X Rays
ddc:550
Established x-ray diffraction methods allow for high-resolution structure determination of crystals, crystallized protein structures, or even single molecules. While these techniques rely on coherent scattering, incoherent processes like fluorescence emission—often the predominant scattering mechanism—are generally considered detrimental for imaging applications. [...]
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2017-11-26
12:49
OpenAccess [PUBDB-2017-12328] Journal Article
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Correlations in Scattered X-Ray Laser Pulses Reveal Nanoscale Structural Features of Viruses
ddc:550
We use extremely bright and ultrashort pulses from an x-ray free-electron laser (XFEL) to measure correlations in x rays scattered from individual bioparticles. This allows us to go beyond the traditional crystallography and single-particle imaging approaches for structure investigations [...]
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2017-11-22
09:49
OpenAccess [PUBDB-2017-12223] Journal Article
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Ternary structure reveals mechanism of a membrane diacylglycerol kinase
ddc:500
iacylglycerol kinase catalyses the ATP-dependent conversion of diacylglycerol to phosphatidic acid in the plasma membrane of Escherichia coli. The small size of this integral membrane trimer, which has 121 residues per subunit, means that available protein must be used economically to craft three catalytic and substrate-binding sites centred about the membrane/cytosol interface [...]
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2017-11-21
18:55
OpenAccess [PUBDB-2017-12204] Dissertation / PhD Thesis
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Structural modification of solids by ultra-short X-ray laser pulses
252 pp. (2017) [10.3204/PUBDB-2017-12204] = Dissertation, University of Hamburg, 2017  GO
The motivation behind this Ph.D. project is to determine the structural modification of solids by ultra-short X-ray laser pulses. [...]
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2017-11-09
11:07
[PUBDB-2017-11815] Contribution to a book
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Processing of XFEL Data
Protein Crystallography / Wlodawer, Alexander (Editor) ; New York, NY : Springer New York, 2017, Chapter 13 ; ISSN: 1064-3745=1940-6029 ; ISBN: 978-1-4939-6998-2=978-1-4939-7000-1 ; doi:10.1007/978-1-4939-7000-1 New York, NY : Springer New York, Methods in Molecular Biology, 1607, 325-347 (2017) [10.1007/978-1-4939-7000-1_13]  GO
ddc:570
The introduction of the X-ray laser to crystallography, and its impact on the types of crystallographic experiments being performed as described in the previous chapter, has meant that new data processing strategies had to be found. While some XFEL crystallography experiments approach the conventional methods quite closely, even those are not without special considerations relating to data processing. [...]
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2017-11-09
11:02
[PUBDB-2017-11813] Journal Article
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Structural basis for selectivity and diversity in angiotensin II receptors
Nature 544(7650), 327 - 332 (2017) [10.1038/nature22035]  GO
ddc:070
The angiotensin II receptors AT1R and AT2R serve as key components of the renin–angiotensin–aldosterone system. AT1R has a central role in the regulation of blood pressure, but the function of AT2R is unclear and it has a variety of reported effects. [...]
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2017-11-03
11:34
OpenAccess [PUBDB-2017-11676] Journal Article
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Pink-beam serial crystallography
ddc:500
Serial X-ray crystallography allows macromolecular structure determination at both X-ray free electron lasers (XFELs) and, more recently, synchrotron sources. The time resolution for serial synchrotron crystallography experiments has been limited to millisecond timescales with monochromatic beams. [...]
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2017-10-26
09:09
OpenAccess [PUBDB-2017-11560] Journal Article
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Hit detection in serial femtosecond crystallography using X-ray spectroscopy of plasma emission
IUCrJ 4(6), 778 - 784 (2017) [10.1107/S2052252517014154]  GO
ddc:530
Serial femtosecond crystallography is an emerging and promising method for determining protein structures, making use of the ultrafast and bright X-ray pulses from X-ray free-electron lasers. The upcoming X-ray laser sources will produce well above 1000 pulses per second and will pose a new challenge: how to quickly determine successful crystal hits and avoid a high-rate data deluge [...]
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2017-10-24
11:53
OpenAccess [PUBDB-2017-11523] Journal Article
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Analysis of XFEL serial diffraction data from individual crystalline fibrils
IUCrJ 4(6), 795 - 811 (2017) [10.1107/S2052252517014324]  GO
ddc:530
Serial diffraction data collected at the Linac Coherent Light Source from crystalline amyloid fibrils delivered in a liquid jet show that the fibrils are well oriented in the jet. At low fibril concentrations, diffraction patterns are recorded from single fibrils; these patterns are weak and contain only a few reflections [...]
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2017-10-24
11:41
[PUBDB-2017-11522] Journal Article
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Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors
Cell 170(3), 457 - 469 (2017) [10.1016/j.cell.2017.07.002]  GO
ddc:570
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