CFEL-I

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2019-01-07
18:39
[PUBDB-2019-00072] Journal Article

X-Ray Free-Electron Lasers for the Structure and Dynamics of Macromolecules
Annual review of biochemistry 88(1), annurev-biochem-013118-110744 () [10.1146/annurev-biochem-013118-110744]  GO
X-ray free-electron lasers provide femtosecond-duration pulses of hard X-rays with a peak brightness approximately one billion times greater than is available at synchrotron radiation facilities. One motivation for the development of such X-ray sources was the proposal to obtain structures of macromolecules, macromolecular complexes, and virus particles, without the need for crystallization, through diffraction measurements of single non- crystalline objects [...]
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2019-01-04
15:46
OpenAccess [PUBDB-2019-00046] Journal Article
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Ab initio phasing of the diffraction of crystals with translational disorder
To date X-ray protein crystallography is the most successful technique available for the determination of high-resolution 3D structures of biological molecules and their complexes. In X-ray protein crystallography the structure of a protein is refined against the set of observed Bragg reflections from a protein crystal. [...]
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2018-12-14
12:59
OpenAccess [PUBDB-2018-05499] Journal Article
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De novo protein structure determination by heavy-atom soaking in lipidic cubic phase and SIRAS phasing using serial synchrotron crystallography
IUCrJ 5(5), 524 - 530 () [10.1107/S2052252518009223]  GO
During the past few years, serial crystallography methods have undergone continuous development and serial data collection has become well established at high-intensity synchrotron-radiation beamlines and XFEL radiation sources. However, the application of experimental phasing to serial crystallography data has remained a challenging task owing to the inherent inaccuracy of the diffraction data [...]
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2018-11-30
16:53
OpenAccess [PUBDB-2018-05098] Journal Article
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Localising functionalised gold-nanoparticles in murine spinal cords by X-ray fluorescence imaging and background-reduction through spatial filtering for human-sized objects
Accurate in vivo localisation of minimal amounts of functionalised gold-nanoparticles, enabling e.g. early-tumour diagnostics and pharmacokinetic tracking studies, requires a precision imaging system offering very high sensitivity, temporal and spatial resolution, large depth penetration, and arbitrarily long serial measurements. [...]
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2018-11-29
16:49
OpenAccess [PUBDB-2018-05022] Journal Article
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Hard x-ray multi-projection imaging for single-shot approaches
Optica 5(12), 1521 - 1524 () [10.1364/OPTICA.5.001521]  GO
High-brilliance x-ray sources (x-ray free-electron lasers or diffraction-limited storage rings) allow the visualization of ultrafast processes in a 2D manner using single exposures. Current 3D approaches scan the sample using multiple exposures, and hence they are not compatible with single-shot acquisitions [...]
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2018-11-26
21:37
OpenAccess [PUBDB-2018-04825] Journal Article

Biological single-particle imaging using XFELs – towards the next resolution revolution
IUCrJ 5(6), 663 - 666 () [10.1107/S2052252518015129]  GO
The development of X-ray free-electron lasers (XFELs) has opened the possibility to investigate the ultrafast dynamics of biomacromolecules using X-ray diffraction. Whereas an increasing number of structures solved by means of serial femtosecond crystallography at XFELs is available, the effect of radiation damage on protein crystals during ultrafast exposures has remained an open question. [...]
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2018-11-26
21:05
OpenAccess [PUBDB-2018-04823] Journal Article
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Structure-factor amplitude reconstruction from serial femtosecond crystallography of two-dimensional membrane-protein crystals
IUCrJ 6(1), 1-12 () [10.1107/S2052252518014641]  GO
Serial femtosecond crystallography of two-dimensional membrane-protein crystals at X-ray free-electron lasers has the potential to address the dynamics of functionally relevant large-scale motions, which can be sterically hindered in three-dimensional crystals and suppressed in cryocooled samples. In previous work, diffraction data limited to a two-dimensional reciprocal-space slice were evaluated and it was demonstrated that the low intensity of the diffraction signal can be overcome by collecting highly redundant data, thus enhancing the achievable resolution [...]
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2018-11-12
15:08
OpenAccess [PUBDB-2018-04432] Dissertation / PhD Thesis
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Novel Approaches to the Production & Analysis of Biological Nanomaterials for Serial- Femtosecond X-ray Crystallography
181 pp. () [10.3204/PUBDB-2018-04432] = Dissertation, University of Hamburg, 2018  GO
Tremendous effort has recently been put into the development of novel methods and techniques in the realm of serial-femtosecond x-ray crystallography (SFX) and x-ray free-electron lasers (XFEL). This thesis strives to contribute to current research approaches. [...]
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2018-11-12
14:52
OpenAccess [PUBDB-2018-04428] Book/Report/Dissertation / PhD Thesis
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Optical and aerodynamic focusing of isolated particles for diffractive imaging experiments at X-ray free electron lasers
[DESY-THESIS-2018-034]
Hamburg : Verlag Deutsches Elektronen-Synchrotron, DESY-THESIS 191 pp. () [10.3204/PUBDB-2018-04428] = Dissertation, Universität Hamburg, 2018  GO
The highly brilliant, short and coherent pulses produced by X-ray free-electron lasers (XFELs) opened up a unique opportunity to image small objects in nature, such as protein macromolecules, clusters, viruses and nanoparticles with nearly atomic spatial resolution, and their dynamic processes can be probed with femtosecond temporal resolution. Single-particle imaging (SPI) is a coherent diffraction imaging technique at XFELs that consists of directing a stream of randomly oriented isolated bio-particles across the focus of the X-ray beam to construct high-resolution 3D structure from diffraction patterns of multiple identical particles. [...]
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2018-11-12
13:55
[PUBDB-2018-04415] Report/Internal Report
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TESLA, The Superconducting Electron Positron Linear Collider with an Integrated X-ray Laser Laboratory, Technical Design Report Part 1
[hep-ph/0106314; DESY-01-011A; TESLA Report 2001-23; TESLA-FEL 2001-05; ECFA-2001-209]
82 pp. ()
The TESLA Technical Design Report Part I: Executive summary
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