CFEL-I

Latest additions:
2020-02-11
16:11
OpenAccess [PUBDB-2020-00687] Journal Article
et al
Ultracompact 3D microfluidics for time-resolved structural biology
To advance microfluidic integration, we present the use of two-photon additive manufacturing to fold 2D channel layouts into compact free-form 3D fluidic circuits with nanometer precision. We demonstrate this technique by tailoring microfluidic nozzles and mixers for time-resolved structural biology at X-ray free-electron lasers (XFELs). [...]
OpenAccess: Download fulltextPDF Download fulltextPDF (PDFA);
ddc:500
Detailed record - Similar records
2020-01-31
12:48
DBCoverage [PUBDB-2020-00623] Journal Article
et al
Ultracompact 3D microfluidics for time-resolved structural biology
Fulltext: Download fulltextPDF; Restricted: Download fulltextPDF Download fulltextPDF (PDFA);
ddc:500
Detailed record - Similar records
2020-01-30
21:51
OpenAccess [PUBDB-2020-00621] Journal Article
et al
In cellulo crystallization of Trypanosoma brucei IMP dehydrogenase enables the identification of genuine co-factors
Sleeping sickness is a fatal disease caused by the protozoan parasite Trypanosoma brucei (Tb). Inosine-5’-monophosphate dehydrogenase (IMPDH) has been proposed as a potential drug target, since it maintains the balance between guanylate deoxynucleotide and ribonucleotide levels that is pivotal for the parasite. [...]
OpenAccess: Download fulltextPDF Download fulltextPDF (PDFA);
ddc:500
Detailed record - Similar records
2020-01-15
10:14
OpenAccess [PUBDB-2020-00275] Journal Article
et al
Multimodal X-ray imaging of nanocontainer-treated macrophages and calcium distribution in the perilacunar bone matrix
Studies of biological systems typically require the application of several complementary methods able to yield statistically-relevant results at a unique level of sensitivity. Combined X-ray fluorescence and ptychography offer excellent elemental and structural imaging contrasts at the nanoscale. [...]
Fulltext: Download fulltextPDF Download fulltextPDF (PDFA); OpenAccess: Download fulltextPDF Download fulltextPDF (PDFA);
ddc:600
Detailed record - Similar records
2020-01-13
15:10
OpenAccess [PUBDB-2020-00147] Journal Article
et al
Femtosecond bond breaking and charge dynamics in ultracharged amino acids
Historically, structure determination of nanocrystals, proteins, and macromolecules required the growth of high-quality crystals sufficiently large to diffract X-rays efficiently while withstanding radiation damage. The development of the X-ray free-electron laser has opened the path toward high resolution single particle imaging, and the extreme intensity of the X-rays ensures that enough diffraction statistics are collected before the sample is destroyed by radiation damage. [...]
OpenAccess: Download fulltextPDF Download fulltextPDF (PDFA);
ddc:530
Detailed record - Similar records
2020-01-13
15:09
[PUBDB-2020-00146] Journal Article
et al
The Karabo distributed control system
The Karabo distributed control system has been developed to address the challenging requirements of the European X-ray Free Electron Laser facility, including complex and custom-made hardware, high data rates and volumes, and close integration of data analysis for distributed processing and rapid feedback. Karabo is a pluggable, distributed application management system forming a supervisory control and data acquisition environment as part of a distributed control system. [...]
Fulltext: Download fulltextPDF Download fulltextPDF (PDFA);
ddc:550
Detailed record - Similar records
2020-01-13
14:56
[PUBDB-2020-00144] Journal Article
et al
Co-crystal structure of the i Mango-III fluorescent RNA aptamer using an X-ray free-electron laser
Turn-on aptamers are in vitro-selected RNAs that bind to conditionally fluorescent small molecules and enhance their fluorescence. Upon binding TO1-biotin, the iMango-III aptamer achieves the largest fluorescence enhancement reported for turn-on aptamers (over 5000-fold). [...]
Restricted: Download fulltextPDF Download fulltextPDF (PDFA);
ddc:530
Detailed record - Similar records
2020-01-13
14:19
[PUBDB-2020-00138] Journal Article
et al
Protein phase separation and determinants of in cell crystallization
Traffic 21(2), 220 - 230 () [10.1111/tra.12711]  GO
Liquid‐liquid phase separation (LLPS) in cells is known as a complex physicochemical process causing the formation of membrane‐less organelles (MLOs). Cells have well‐defined different membrane‐surrounded organelles like mitochondria, endoplasmic reticulum, lysosomes, peroxisomes, etc., however, on demand they can create MLOs as stress granules, nucleoli and P bodies to cover vital functions and regulatory activities. [...]
Restricted: Download fulltextPDF Download fulltextPDF (PDFA);
ddc:570
Detailed record - Similar records
2020-01-13
14:14
OpenAccess [PUBDB-2020-00136] Journal Article
et al
Tracking multiple components of a nuclear wavepacket in photoexcited Cu(I)-phenanthroline complex using ultrafast X-ray spectroscopy
Disentangling the strong interplay between electronic and nuclear degrees of freedom is essential to achieve a full understanding of excited state processes during ultrafast nonadiabatic chemical reactions. However, the complexity of multi-dimensional potential energy surfaces means that this remains challenging. [...]
OpenAccess: Download fulltextPDF Download fulltextPDF (PDFA);
ddc:500
Detailed record - Similar records
2020-01-10
16:12
OpenAccess [PUBDB-2020-00124] Journal Article
et al
pinkIndexer – a universal indexer for pink-beam X-ray and electron diffraction snapshots
A crystallographic indexing algorithm, pinkIndexer, is presented for the analysis of snapshot diffraction patterns. It can be used in a variety of contexts including measurements made with a monochromatic radiation source, a polychromatic source or with radiation of very short wavelength. [...]
Fulltext: Download fulltextPDF Download fulltextPDF (PDFA); OpenAccess: Download fulltextPDF Download fulltextPDF (PDFA);
ddc:530
Detailed record - Similar records