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OpenAccess [PUBDB-2020-00621] Journal Article
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In cellulo crystallization of Trypanosoma brucei IMP dehydrogenase enables the identification of genuine co-factors
Sleeping sickness is a fatal disease caused by the protozoan parasite Trypanosoma brucei (Tb). Inosine-5’-monophosphate dehydrogenase (IMPDH) has been proposed as a potential drug target, since it maintains the balance between guanylate deoxynucleotide and ribonucleotide levels that is pivotal for the parasite. [...]
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Embargoed OpenAccess [PUBDB-2017-00953] Journal Article
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Atomic Structure of Granulin Determined from Native Nanocrystalline Granulovirus Using an X-ray Free-Electron Laser
To understand how molecules function in biological systems, new methods are required to obtain atomic resolution structures from biological material under physiological conditions. Intense femtosecond-duration pulses from X-ray free-electron lasers (XFELs) can outrun most damage processes, vastly increasing the tolerable dose before the specimen is destroyed. [...]
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OpenAccess [PUBDB-2016-06266] Journal Article
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Structural enzymology using X-ray free electron lasers
Structural dynamics 4(4), 044003 () [10.1063/1.4972069]  GO
Mix-and-inject serial crystallography (MISC) is a technique designed to image enzyme catalyzed reactions in which small protein crystals are mixed with a substrate just prior to being probed by an X-ray pulse. This approach offers several advantages over flow cell studies. [...]
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OpenAccess [PUBDB-2016-04849] Journal Article
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A data set from flash X-ray imaging of carboxysomes
Ultra-intense femtosecond X-ray pulses from X-ray lasers permit structural studies on single particles and biomolecules without crystals. We present a large data set on inherently heterogeneous, polyhedral carboxysome particles. [...]
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