Journal Article

Ultralight dark matter may couple quadratically to Standard Model particles. Such quadratic interactions give rise to both coherent and stochastic signals in pulsar timing array (PTA) observations. [...]

Residual stresses were quantified in a 316 L stainless steel additive manufacturing benchmark arch to assess part-to-part and machine-to-machine variability and the influence of baseplate during stress-relief heat treatment. Nominally identical arches were built by laser powder bed fusion (LPBF) on a MetalFAB1 and an EOS M290 using each vendor’s recommended process window, then characterized by synchrotron and neutron diffraction. [...]

Ecto-5’-nucleotidase (CD73) is a potential new drug target for cancer immunotherapy. Its overexpression is associated with various aggressive cancers, including triple-negative breast cancer (TNBC) and pancreatic cancer, making it a promising target for diagnostic imaging. [...]

USP25 and USP28 are critical deubiquitylases (DUBs) that have been implicated in various diseases, particularly cancer and cardiac dysfunction. Several small-molecule inhibitors have been reported, exhibiting dual inhibitory activity in the low micromolar range. [...]

TBC (Tre2/Bub2/Cdc16) domain-containing proteins constitute the widespread family of GTPase-activating proteins (GAPs). They interact with the Rab superfamily of small GTPases, stimulate GTP hydrolysis, and regulate vesicle trafficking. [...]

The evolution of C4 photosynthesis required extensive modification of ancestral enzymes enabling the development of anefficient carbon concentrating mechanism. A key example is NADP-malic enzyme (NADP-ME), which, in maize and sorghum—members of the same C4 lineage—underwent gene duplication and neofunctionalization, resulting in 2 plastidic isoformswith distinct oligomeric states: a tetrameric C4-specific isoform and a dimeric housekeeping (nonC4) isoform. [...]