Journal Article

For over two decades, the dCache project has provided open-source software to satisfy ever-more demanding storage requirements. More than 80 sites worldwide rely on dCache to provide services for LHC experiments, Belle-II, Eu-XFEL, and others. [...]

Traditional filesystems organize data in directories. These directories are typically a collection of files whose grouping is based on a single criterion, e.g., the starting date of an experiment, experiment name, beamline ID, measurement device, or instrument. [...]

We report observations of the ultra-high-energy gamma-ray source LHAASO J2108+5157, utilizing VERITAS, HAWC, Fermi-LAT, and XMM-Newton. VERITAS has collected ∼40 hr of data that we used to set ULs to the emission above 200 GeV [...]

In this article we examine recent developments in the research area concerning the creation of end-to-end models for the complete optimization of measuring instruments. The models we consider rely on differentiable programming methods and on the specification of a software pipeline including all factors impacting performance — from the data-generating processes to their reconstruction and the inference on the parameters of interest — along with the careful specification of a utility function well aligned with the end goals of the experiment.Building on previous studies originated within the MODE Collaboration, we focus specifically on applications involving instruments for particle physics experimentation, as well as industrial and medical applications that share the detection of radiation as their data-generating mechanism.This report illustrates the most recent advancements in the area, and outlines, for each of the discussed applications as well as for automatic differentiation itself, ongoing and future work [...]

The transfer of inorganic nanoparticles (NPs) into water is usually considered a challenge, as NPs are preferably synthesized in organic solvents and commonly bear hydrophobic ligands. Consequently, various methods have been reported to achieve their transfer to aqueous media. [...]

Sanggenon C (SGC) and sanggenon D (SGD) are stereoisomeric natural products with promising anti-infective potential, especially against pathogens involved in acute respiratory infections. However, their bulky structures, poor aqueous solubility, and low oral bioavailability present major therapeutic challenges. [...]