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2017-05-18
16:59
OpenAccess [PUBDB-2017-03182] Journal Article
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Structural insights into the mechanism of the DEAH-box RNA helicase Prp43
eLife 6, e21510 (2017) [10.7554/eLife.21510]  GO
ddc:500
The DEAH-box helicase Prp43 is a key player in pre-mRNA splicing as well as the maturation of rRNAs. The exact modus operandi of Prp43 and of all other spliceosomal DEAH-box RNA helicases is still elusive. [...]
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2017-05-17
16:37
OpenAccess [PUBDB-2017-03142] Journal Article
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Crystal Structure of Bombyx mori Lipoprotein 6: Comparative Structural Analysis of the 30-kDa Lipoprotein Family
PLoS one 9(11), e108761 - (2014) [10.1371/journal.pone.0108761]  GO
ddc:500
The 30-kDa lipoprotein (LP) family of mulberry silkworm comprises major hemolymph proteins specific to the fifth instar larvae. The family consists of 46 members, 24 of which are referred to as typical 30-kDa LPs. [...]
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2017-05-16
14:47
OpenAccess [PUBDB-2017-03016] Contribution to a conference proceedings/Contribution to a book
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Performance-Portable Many-Core Plasma Simulations: Porting PIConGPU to OpenPower and Beyond
ISC High Performance 2016: High Performance Computing
International Conference on High Performance Computing, Meeting locationFrankfurt, Germany, 19 Jun 2016 - 23 Jun 20162016-06-192016-06-23
Lecture Notes in Computer Science 9945, 293 - 301 (2016) [10.1007/978-3-319-46079-6_21]  GO
ddc:004
With the appearance of the heterogeneous platform OpenPower,many-core accelerator devices have been coupled with Power host processors for the first time. Towards utilizing their full potential, it is worth investigating performance portable algorithms that allow to choose the best-fitting hardware for each domain-specific compute task. [...]
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2017-05-16
14:26
OpenAccess [PUBDB-2017-03012] Report/Contribution to a conference proceedings/Contribution to a book
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Alpaka -- An Abstraction Library for Parallel Kernel Acceleration
[1602.08477]
2016 IEEE International Parallel and Distributed Processing Symposium Workshops (IPDPSW) : [Proceedings] - IEEE, 2016. - ISBN 978-1-5090-3682-0 - doi:10.1109/IPDPSW.2016.50
2016 IEEE International Parallel and Distributed Processing Symposium Workshops (IPDPSW), Meeting locationChicago, USA, 23 May 2016 - 27 May 20162016-05-232016-05-27
631-640 (2016) [10.1109/IPDPSW.2016.50]  GO
Porting applications to new hardware or programming models is a tedious and error prone process. Every help that eases these burdens is saving developer time that can then be invested into the advancement of the application itself instead of preserving the status-quo on a new platform. [...]
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2017-05-15
14:17
OpenAccess [PUBDB-2017-02927] Journal Article
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Structural basis of myelin-associated glycoprotein adhesion and signalling
ddc:500
Myelin-associated glycoprotein (MAG) is a myelin-expressed cell-adhesion and bi-directional signalling molecule. MAG maintains the myelin–axon spacing by interacting with specific neuronal glycolipids (gangliosides), inhibits axon regeneration and controls myelin formation. [...]
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2017-05-15
14:12
OpenAccess [PUBDB-2017-02924] Journal Article
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Structural and Catalytic Properties of S1 Nuclease from Aspergillus oryzae Responsible for Substrate Recognition, Cleavage, Non–Specificity, and Inhibition
PLoS one 11(12), e0168832 - (2016) [10.1371/journal.pone.0168832]  GO
ddc:500
The single–strand–specific S1 nuclease from Aspergillus oryzae is an archetypal enzyme of the S1–P1 family of nucleases with a widespread use for biochemical analyses of nucleic acids. We present the first X–ray structure of this nuclease along with a thorough analysis of the reaction and inhibition mechanisms and of its properties responsible for identification and binding of ligands. [...]
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2017-05-15
13:37
OpenAccess [PUBDB-2017-02915] Journal Article
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Intrinsic Disorder of the C-Terminal Domain of Drosophila Methoprene-Tolerant Protein
PLoS one 11(9), e0162950 - (2016) [10.1371/journal.pone.0162950]  GO
ddc:500
Methoprene tolerant protein (Met) has recently been confirmed as the long-sought juvenile hormone (JH) receptor. This protein plays a significant role in the cross-talk of the 20-hydroxyecdysone (20E) and JH signalling pathways, which are important for control of insect development and maturation. [...]
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2017-05-15
13:20
OpenAccess [PUBDB-2017-02909] Journal Article
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High-throughput and time-resolved BioSAXS at the P12 beamline of EMBL Hamburg
ddc:530
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2017-05-15
13:15
OpenAccess [PUBDB-2017-02907] Journal Article
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Rapid automated superposition of shapes and macromolecular models using spherical harmonics
ddc:540
A rapid algorithm to superimpose macromolecular models in Fourier space is proposed and implemented (SUPALM). The method uses a normalized integrated cross-term of the scattering amplitudes as a proximity measure between two three-dimensional objects. [...]
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2017-05-15
13:09
OpenAccess [PUBDB-2017-02903] Journal Article
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Restriction endonuclease AgeI is a monomer which dimerizes to cleave DNA
ddc:540
Although all Type II restriction endonucleases catalyze phosphodiester bond hydrolysis within or close to their DNA target sites, they form different oligomeric assemblies ranging from monomers, dimers, tetramers to higher order oligomers to generate a double strand break in DNA. Type IIP restriction endonuclease AgeI recognizes a palindromic sequence 5΄-A/CCGGT-3΄ and cuts it (‘/’ denotes the cleavage site) producing staggered DNA ends. [...]
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