OpenAccess

Homology Directed Repair (HDR) enables precise genome editing, but the implementation of HDR-based therapies is hindered by limited efficiency in comparison to methods that exploit alternative DNA repair routes, such as Non-Homologous End Joining (NHEJ). In this study, we develop a functional, pooled screening platform to identify protein-based reagents that improve HDR in human hematopoietic stem and progenitor cells (HSPCs). [...]

Nanoporosity in silicon leads to completely new functionalities of this mainstream semiconductor.In recent years, it has been shown that filling the pores with aqueous electrolytes in addition opensa particularly wide field for modifying and achieving active control of these functionalities, e.g.,for electrochemo-mechanical actuation and tunable photonics, or for the design of on-chip superca-pacitors. However, a mechanistic understanding of these new features has been hampered by thelack of a detailed characterization of the electrochemical behavior of mesoporous silicon in aqueouselectrolytes. [...]

Al-alloys incorporating Mn, Cr and Zr, tailored forpowder bed fusion-laser beam processes with solubilitiesthree times equilibrium have recently beendeveloped that yield a high strength. Mn andCr-enriched precipitates that form during printingand heat treatment influence the material’s mechanicalproperties hence making it important to understandtheir kinetics. [...]

We have used in situ X-ray photoelectron spectroscopy to obtain information about the chemical state of a Fe single crystal catalyst upon addition of CO$_2$ in the syngas feed duringFischer−Tropsch synthesis (FTS) between 85 and 550 mbar. We found that at certain temperatures, the ternary mixture of CO, CO$_2$, and H$_2$ yields a chemical state which is resemblant of neither the CO hydrogenation nor the CO$_2$ hydrogenation reaction mixtures in isolation [...]

This paper describes the COMBINE software package used for statistical analyses by the CMS Collaboration. The package, originally designed to perform searches for a Higgs boson and the combined analysis of those searches, has evolved to become the statistical analysis tool presently used in the majority of measurements and searches performed by the CMS Collaboration. [...]

For the first time, we directly measured the onset and completion temperatures of polymorphic transitions under thermo-mechanochemical conditions by simultaneous in situ synchrotron powder X-ray diffraction and temperature monitoring. We determined the thermo-mechanochemical polymorphic transition temperature in 1-adamantyl-1-diamantyl ether to be 31 °C lower than the transition temperature determined by DSC [...]

X-ray diffraction with high spatial resolution is a prerequisite for the characterization of (poly)-crystalline materials on micro- or nanoscopic scales. This can be achieved by utilizing a focused X-ray beam and scanning of the sample. [...]

A search for long-lived heavy neutral leptons (HNLs) is presented, which considers the hadronic final state and coupling scenarios involving all three lepton generations in the 2–20 GeV HNL mass range for the first time. Events comprising two leptons (electrons or muons) and jets are analyzed in a data sample of proton-proton collisions, recorded with the CMS experiment at the CERN LHC at a centre-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 138 fb$^{−1}$ [...]

A search for the production of a top quark in association with a photon and additional jets via flavor changing neutral current interactions is presented. The analysis uses proton-proton collision data recorded by the CMS detector at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 138 fb$^{-1}$ [...]

A search for an exotic decay of the Higgs boson to a Z boson and a light pseudoscalar particle (a), decaying to a pair of leptons and a pair of photons, respectively, is presented. The search is based on proton-proton collision data at a center-of-mass energy of $\sqrt{s}$ = 13 TeV, collected with the CMS detector and corresponding to an integrated luminosity of 138 fb$^{-1}$ [...]