OpenAccess

The SARS-CoV-2 helicase NSP13 is a highly conserved and essential component of the viral replication machinery, making it a promising target for antiviral drug development. Here, we present the 2 Å resolution crystal structure of NSP13 bound to the natural flavonoid myricetin, revealing a conserved allosteric binding site. [...]

first_pagesettingsOrder Article ReprintsOpen AccessArticleNovel Derivatives of 3-Amino-4-hydroxy-benzenesulfonamide: Synthesis, Binding to Carbonic Anhydrases, and Activity in Cancer Cell 2D and 3D Culturesby Valdas Vainauskas1, Rugilė Norvaišaitė2, Birutė Grybaitė1 [ORCID] , Rita Vaickelionienė1, Alexey Smirnov2, Tautvydas Kojis2 [ORCID] , Lina Baranauskiene2 [ORCID] , Elena Manakova3 [ORCID] , Saulius Gražulis4, Asta Zubrienė2 [ORCID] , Daumantas Matulis2 [ORCID] , Vytautas Mickevičius1,* [ORCID] and Vilma Petrikaitė5,6,*1Department of Organic Chemistry, Kaunas University of Technology, Radvilėnų Rd. 19, LT-50254 Kaunas, Lithuania2Department of Biothermodynamics and Drug Design, Institute of Biotechnology, Life Sciences Center, Vilnius University, Saulėtekio 7, LT-10257 Vilnius, Lithuania3Department of Protein–DNA Interactions, Institute of Biotechnology, Life Sciences Center, Vilnius University, Saulėtekio al. [...]

The ReAV enzyme from Rhizobium etli, a representative of Class 3 L-asparaginases, is sequentially and structurally different from other known L-asparaginases. This distinctiveness makes ReAV a candidate for novel antileukemic therapies. [...]

The increase in infections caused by multi-resistant Gram-negative bacteria, like Stenotrophomonas maltophilia, has become a growing health crisis worldwide. S. [...]

This paper presents the first observation of top-quark pair production in association with two photons ($t\bar{t}\gamma\gamma$). The measurement is performed in the single-lepton decay channel using proton-proton collision data collected by the ATLAS detector at the Large Hadron Collider. [...]

A search for single production of a vector-like quark $Q$, which could be either a singlet $T$, with charge $\tfrac23$, or a $Y$ from a $(T,B,Y)$ triplet, with charge $-\tfrac43$, is performed using data from proton-proton collisions at a centre-of-mass energy of 13 TeV. The data correspond to the full integrated luminosity of 140 fb$^{-1}$ recorded with the ATLAS detector during Run 2 of the Large Hadron Collider. [...]

A search for R-parity-conserving supersymmetry in events with large missing transverse momentum, jets and at least one hadronically decaying $τ$-lepton is presented. Both gluino and squark pair production are considered, with the cascade decay of each gluino or squark producing either a $τ$-slepton or a $τ$-sneutrino. [...]

A search for exotic decays of the Higgs boson $H$ into new scalar or pseudoscalar particles that subsequently decay into $b$-quarks is presented. The search considers $ZH$ production with several decay scenarios for the Higgs boson: first to a pair of identical scalars, $H\rightarrow 2a \rightarrow 4b$, second to a pair of scalars with different masses ($m_{a1}<m_{a2}$), either directly, $H\rightarrow a_1a_2 \rightarrow 4b$, or via a longer decay chain, $H \rightarrow a_1a_2 \rightarrow 3a_1 \rightarrow 6b$. [...]

A measurement of the top-quark pole mass $m_{t}^\text{pole}$ is presented in $t\bar{t}$ events with an additional jet, $t\bar{t}+1\text{-jet}$, produced in $pp$ collisions at $\sqrt{s}=13$ TeV. The data sample, recorded with the ATLAS experiment during Run 2 of the LHC, corresponds to an integrated luminosity of 140 $\text{fb}^{-1}$. [...]

We present version 2.2 of the High Energy Jets (HEJ) Monte Carlo event generator for hadronic scattering processes at high energies. The new version adds support for two further processes of central phenomenological interest, namely the production of a W boson pair with equal charge together with two or more jets and the production of a Higgs boson with at least one jet. [...]